The Emergence of Viral Encephalitis in Donkeys by Equid Herpesvirus 8 in China.
EHV-8
donkey
mice
neurological diseases
pathogenicity
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
12
2021
accepted:
07
01
2022
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
The equine herpesvirus type 8 (EHV-8) can cause significant economic losses in the global horses and donkey industry. The disease has been associated with abortion and respiratory symptoms. However, it is rare for a study to be reported about donkeys with neurological diseases induced by EHV-8 infection. In the present study, one 2-year-old male donkey, from a large-scale donkey farm in China, died with a severe neurological disorder. The causative agent, donkey/Shandong/10/2021 (GenBank accession: OL856098), was identified and isolated from the brain tissue of the dead donkey. Meanwhile, BALB/c mice were used as an animal model to evaluate the pathogenicity of the EHV-8 isolate. Our data showed that EHV-8 was positive in brains by PCR and immunohistochemistry, which induced typical viral encephalitis lesions in both donkey and mice consistent with clinical signs. For the first time, we reported that EHV-8 had been isolated from donkeys with a neurological illness in China, which is helpful to reveal the pathogenicity of EHV-8 in the donkey.
Identifiants
pubmed: 35308333
doi: 10.3389/fmicb.2022.840754
pmc: PMC8930201
doi:
Types de publication
Journal Article
Langues
eng
Pagination
840754Informations de copyright
Copyright © 2022 Wang, Hu, Liu, Wang, Hu, Li, Liu, Li, Wang, Ren, Zhang, Wang and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
PLoS One. 2018 Feb 7;13(2):e0192301
pubmed: 29414990
Vet Microbiol. 2011 May 12;150(1-2):1-14
pubmed: 21292410
J Virol. 2012 May;86(9):5407
pubmed: 22492929
J Vet Med Sci. 2017 Aug 18;79(8):1426-1436
pubmed: 28717112
Arch Virol. 2009;154(1):171-7
pubmed: 19066710
Acta Trop. 2020 May;205:105414
pubmed: 32088277
Infect Dis (Lond). 2016 Aug;48(8):571-86
pubmed: 27207312
Equine Vet J. 2008 Mar;40(2):102-3
pubmed: 18302993
J Spec Oper Med. 2016 Summer;16(2):89-90
pubmed: 27450609
Vet J. 2011 Jul;189(1):7-14
pubmed: 20685140
Int J Vet Sci Med. 2020 Mar 31;8(1):26-30
pubmed: 32341914
J Vet Sci. 2012 Jun;13(2):111-8
pubmed: 22705732
Arch Virol. 1988;101(3-4):183-90
pubmed: 2845891
Transbound Emerg Dis. 2018 Jun;65(3):817-832
pubmed: 29423949
Pol J Vet Sci. 2014;17(4):607-12
pubmed: 25638974
J Comp Pathol. 2011 Feb-Apr;144(2-3):103-12
pubmed: 20813378
J Vet Diagn Invest. 2012 Jul;24(4):767-71
pubmed: 22585954
J Gen Virol. 1993 Nov;74 ( Pt 11):2339-45
pubmed: 8245851
Int J Clin Exp Med. 2015 Nov 15;8(11):20953-8
pubmed: 26885024
An Acad Bras Cienc. 2020 Sep 18;92(suppl 2):e20180837
pubmed: 32965312
Vet Pathol. 2019 Sep;56(5):691-702
pubmed: 30686182
Animals (Basel). 2020 Aug 07;10(8):
pubmed: 32784541
Vet Microbiol. 2017 May;203:117-124
pubmed: 28619133
Equine Vet J. 2019 Nov;51(6):756-759
pubmed: 30868638
J Comp Pathol. 2004 Nov;131(4):277-84
pubmed: 15511536
J Equine Vet Sci. 2020 Nov;94:103247
pubmed: 33077102