Autoimmune Autonomic Ganglionopathy Presenting as Constipation.
anorectal manometry
autoimmune autonomic ganglionopathy
constipation
pelvic floor dysfunction
peripheral neuropathy
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
accepted:
08
02
2022
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
Autoimmune autonomic ganglionopathy (AAG) is a rare post-ganglionic disorder that causes a range of symptoms, often including gastrointestinal disorders. Patients may be seropositive or seronegative for antibodies against the nicotinic acetylcholine receptor. Here, we describe the case of a 56-year-old woman with a previous diagnosis of sensorimotor peripheral neuropathy who presented with severe constipation that was not responsive to laxative therapy. The evaluation showed diffuse colonic hypomotility, rectal hypersensitivity, and type IV pelvic floor dysfunction. The patient was diagnosed 10 months after the presentation as having seronegative AAG, and she responded well to treatment with intravenous methylprednisolone and apheresis.
Identifiants
pubmed: 35308659
doi: 10.7759/cureus.22108
pmc: PMC8918276
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e22108Informations de copyright
Copyright © 2022, Ahmed et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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