Three Classes of Antioxidant Defense Systems and the Development of Postmenopausal Osteoporosis.
GSH/GSSG
PI3K/AKT/Nrf2/HO-1
antioxidant system
oxidative stress
postmenopausal osteoporosis
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
12
2021
accepted:
25
01
2022
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
Osteoporosis is a common bone imbalance disease that threatens the health of postmenopausal women. Estrogen deficiency accelerates the aging of women. Oxidative stress damage is regarded as the main pathogenesis of postmenopausal osteoporosis. The accumulation of reactive oxygen species in the bone microenvironment plays a role in osteoblast and osteoclast apoptosis. Improving the oxidative state is essential for the prevention and treatment of postmenopausal osteoporosis. There are three classes of antioxidant defense systems in the body to eliminate free radicals and peroxides including antioxidant substances, antioxidant enzymes, and repair enzymes. In our review, we demonstrated the mechanism of antioxidants and their effect on bone metabolism in detail. We concluded that glutathione/oxidized glutathione (GSH/GSSG) conversion involved the PI3K/Akt-Nrf2/HO-1 signaling pathway and that the antioxidant enzyme-mediated mitochondrial apoptosis pathway of osteoblasts was necessary for the development of postmenopausal osteoporosis. Since the current therapeutic effects of targeting bone cells are not significant, improving the systemic peroxidation state and then regulating bone homeostasis will be a new method for the treatment of postmenopausal osteoporosis.
Identifiants
pubmed: 35309045
doi: 10.3389/fphys.2022.840293
pmc: PMC8927967
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
840293Informations de copyright
Copyright © 2022 Yang, Cao, Xue, Tao and Zhu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Prog Lipid Res. 2010 Oct;49(4):438-49
pubmed: 20600307
J Ethnopharmacol. 2020 Feb 10;248:112329
pubmed: 31672526
Genes Genomics. 2021 Oct;43(10):1223-1230
pubmed: 34398448
Exp Gerontol. 2016 Jan;73:49-58
pubmed: 26608808
J Pain Res. 2020 Jan 15;13:131-142
pubmed: 32021402
Best Pract Res Clin Endocrinol Metab. 2021 Dec;35(6):101551
pubmed: 34119418
Calcif Tissue Int. 2020 Mar;106(3):232-238
pubmed: 31754762
Free Radic Biol Med. 1993 Feb;14(2):115-25
pubmed: 8425718
Int J Mol Sci. 2019 May 24;20(10):
pubmed: 31137666
Molecules. 2019 Jul 19;24(14):
pubmed: 31331121
BMC Musculoskelet Disord. 2020 Feb 19;21(1):112
pubmed: 32075617
Int J Mol Med. 2021 Jul;48(1):
pubmed: 34036379
Int J Vitam Nutr Res. 2019 Nov;89(5-6):357-370
pubmed: 30856080
Biofactors. 2003;17(1-4):37-46
pubmed: 12897427
Biomed Pharmacother. 2020 Dec;132:110897
pubmed: 33113431
Adv Pharmacol Sci. 2012;2012:142702
pubmed: 22162676
J Pharmacol Exp Ther. 2007 Feb;320(2):591-8
pubmed: 17082313
Bone. 1996 Sep;19(3):223-6
pubmed: 8873962
Molecules. 2019 Aug 29;24(17):
pubmed: 31470553
Joint Bone Spine. 2009 Oct;76(5):514-8
pubmed: 19464221
BMC Musculoskelet Disord. 2020 Jun 12;21(1):375
pubmed: 32532246
Biomed Res Int. 2018 Sep 27;2018:9156478
pubmed: 30363685
Stem Cells Int. 2019 Sep 5;2019:6403967
pubmed: 31582985
Oncogene. 2021 Oct;40(40):5925-5937
pubmed: 34363021
Free Radic Biol Med. 2010 Aug 15;49(4):587-96
pubmed: 20483371
J Bioenerg Biomembr. 2021 Oct;53(5):525-539
pubmed: 34347214
Pflugers Arch. 2018 Dec;470(12):1721-1737
pubmed: 30120555
Biol Trace Elem Res. 1999 Jun;68(3):193-207
pubmed: 10328336
World J Biol Psychiatry. 2021 Mar;22(3):161-174
pubmed: 32677491
Physiol Rep. 2021 Jan;9(1):e14662
pubmed: 33433056
Dis Markers. 2016;2016:7067984
pubmed: 27594735
Redox Biol. 2021 Oct;46:102099
pubmed: 34509916
J Oleo Sci. 2022;71(1):105-118
pubmed: 35013033
J Clin Invest. 2003 Mar;111(6):821-31
pubmed: 12639988
Arthritis Res Ther. 2018 Sep 10;20(1):208
pubmed: 30201038
J Microbiol Biotechnol. 2020 Oct 28;30(10):1543-1551
pubmed: 32807758
Curr Rheumatol Rep. 2010 Apr;12(2):135-41
pubmed: 20425023
Molecules. 2020 Jun 18;25(12):
pubmed: 32570970
Biomed Pharmacother. 2020 Mar;123:109807
pubmed: 31896066
J Pineal Res. 2011 Sep;51(2):187-94
pubmed: 21470302
Toxicology. 2021 Apr 15;453:152721
pubmed: 33592258
Environ Toxicol Pharmacol. 2021 May;84:103613
pubmed: 33571669
Endocrine. 2013 Feb;43(1):59-64
pubmed: 23055015
Biomed Pharmacother. 2016 Aug;82:399-405
pubmed: 27470378
DNA Cell Biol. 2003 Sep;22(9):541-6
pubmed: 14577906
Mol Ther Nucleic Acids. 2021 Mar 13;24:385-402
pubmed: 33868783
Stem Cells. 2016 Apr;34(4):1054-67
pubmed: 26700816
Clin Geriatr Med. 2002 Aug;18(3):529-55
pubmed: 12424871
Nature. 2014 Jun 12;510(7504):298-302
pubmed: 24805240
J Cell Physiol. 2021 Jun;236(6):4764-4777
pubmed: 33275302
Front Cell Dev Biol. 2021 Jul 08;9:693969
pubmed: 34307369
Bioengineered. 2022 Jan;13(1):1399-1410
pubmed: 34974796
Eur J Nutr. 2020 Aug;59(5):1975-1987
pubmed: 31280345
Indian J Clin Biochem. 2007 Sep;22(2):101-5
pubmed: 23105693
J Biol Regul Homeost Agents. 2015 Jul-Sep;29(3):637-46
pubmed: 26403401
Exp Ther Med. 2021 Nov;22(5):1316
pubmed: 34630670
Nutrients. 2019 Feb 27;11(3):
pubmed: 30818817
Int J Mol Med. 2018 Apr;41(4):2059-2069
pubmed: 29393365
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4409-13
pubmed: 15753298
Exp Cell Res. 2017 Jan 1;350(1):41-49
pubmed: 27832946
Biochem Biophys Res Commun. 2007 Aug 24;360(2):346-51
pubmed: 17597583
Pharmacol Rep. 2012;64(2):396-402
pubmed: 22661191
Hum Exp Toxicol. 2017 Sep;36(9):967-980
pubmed: 28434258
Oxid Med Cell Longev. 2016;2016:3565127
pubmed: 27247702
Antioxidants (Basel). 2020 May 05;9(5):
pubmed: 32380763
Physiol Rev. 2014 Jul;94(3):909-50
pubmed: 24987008
J Clin Invest. 1983 Sep;72(3):826-35
pubmed: 6309911
Food Chem Toxicol. 2004 Mar;42(3):429-38
pubmed: 14871584
Med Sci Monit. 2018 Jul 21;24:5071-5075
pubmed: 30030965
PLoS One. 2011 Mar 29;6(3):e17437
pubmed: 21479266
J Mol Med (Berl). 2017 Oct;95(10):1065-1076
pubmed: 28674855
Oxid Med Cell Longev. 2020 Sep 25;2020:9102012
pubmed: 33062149
Bone. 1995 Aug;17(2):161-5
pubmed: 8554925
Ann Transl Med. 2020 Jul;8(14):852
pubmed: 32793696
Mol Cell Endocrinol. 2008 Aug 13;290(1-2):51-9
pubmed: 18571833
Free Radic Biol Med. 2020 Jan;146:92-106
pubmed: 31669348
Free Radic Res. 2010 Feb;44(2):135-45
pubmed: 20092032
Cytokine. 2020 Sep;133:155166
pubmed: 32570159
BMB Rep. 2008 Aug 31;41(8):560-7
pubmed: 18755070
Cell Biochem Biophys. 2017 Dec;75(3-4):319-333
pubmed: 28401421
Ann Intern Med. 2017 Jun 6;166(11):818-839
pubmed: 28492856
Molecules. 2021 Apr 21;26(9):
pubmed: 33919399
Int J Endocrinol. 2020 Jun 29;2020:3082318
pubmed: 32676109
Nat Med. 2009 Jun;15(6):682-9
pubmed: 19448637
Mediators Inflamm. 2019 Feb 12;2019:8597159
pubmed: 30890898
Metabolism. 2018 Jun;83:167-176
pubmed: 29378199
Oral Dis. 2007 Jan;13(1):32-9
pubmed: 17241427
Life Sci. 2020 Sep 15;257:118044
pubmed: 32622944
Eur J Immunol. 2021 Apr;51(4):903-914
pubmed: 33347617
J Cell Physiol. 2021 May;236(5):3495-3509
pubmed: 33030247
Chem Phys Lipids. 2008 Feb;151(2):77-84
pubmed: 17996197
J Bone Miner Metab. 2020 Jan;38(1):27-37
pubmed: 31493249
J Gene Med. 2020 Oct;22(10):e3214
pubmed: 32391643
J Biochem Mol Toxicol. 2020 Nov;34(11):e22563
pubmed: 32830409
Indian J Exp Biol. 2002 Nov;40(11):1213-32
pubmed: 13677623
Biology (Basel). 2021 Jan 12;10(1):
pubmed: 33445531
Biochemistry. 2006 Mar 14;45(10):3429-36
pubmed: 16519538
J Adv Res. 2017 Sep;8(5):537-548
pubmed: 28748119
J Bone Miner Res. 2011 Nov;26(11):2682-94
pubmed: 22025246
Bone. 2014 Oct;67:200-7
pubmed: 25019595
Pharmacol Res. 2021 Dec;174:105967
pubmed: 34740817
Nutrients. 2020 Jul 13;12(7):
pubmed: 32668691
ACS Cent Sci. 2020 Oct 28;6(10):1835-1843
pubmed: 33145420
Life Sci. 2020 Apr 1;246:117422
pubmed: 32057903
Cells. 2020 Jul 29;9(8):
pubmed: 32751118
J Bone Miner Res. 2010 Jan;25(1):164-72
pubmed: 19821764
N Engl J Med. 2016 Jan 21;374(3):254-62
pubmed: 26789873
PLoS One. 2017 Aug 28;12(8):e0183506
pubmed: 28847008
Front Endocrinol (Lausanne). 2020 Sep 08;11:613
pubmed: 33013696
JBMR Plus. 2021 Apr 02;5(4):e10488
pubmed: 33869998
IUBMB Life. 2021 Feb;73(2):432-443
pubmed: 33336851
J Pineal Res. 2021 Aug;71(1):e12749
pubmed: 34085304
Endocr Metab Immune Disord Drug Targets. 2020;20(9):1478-1487
pubmed: 32496996
Acta Biochim Biophys Sin (Shanghai). 2020 Oct 19;52(10):1055-1062
pubmed: 33085739
J Cell Physiol. 2007 May;211(2):457-67
pubmed: 17186497
Arch Med Res. 2007 Feb;38(2):196-205
pubmed: 17227729
Bioresour Technol. 2020 Jul;307:123234
pubmed: 32245673
Circ Res. 2007 May 25;100(10):1512-21
pubmed: 17446436
Int J Mol Sci. 2019 Mar 22;20(6):
pubmed: 30909398
Chem Biol Interact. 2014 Dec 5;224:164-75
pubmed: 25452175
Cell Biochem Funct. 2010 Dec 2;28(8):678-85
pubmed: 21104936
Free Radic Biol Med. 2021 May 20;168:234-246
pubmed: 33781894
Free Radic Biol Med. 2021 Aug 1;171:365-378
pubmed: 34000381
DNA Repair (Amst). 2016 Dec;48:43-50
pubmed: 27818081
Circ Res. 2018 Mar 16;122(6):877-902
pubmed: 29700084
Free Radic Biol Med. 2019 Jan;130:328-342
pubmed: 30412732
Arch Biochem Biophys. 2001 Oct 1;394(1):117-35
pubmed: 11566034
Front Pharmacol. 2021 Nov 26;12:774709
pubmed: 34899338
Oxid Med Cell Longev. 2019 Apr 11;2019:4019619
pubmed: 31110599
Aquat Toxicol. 2018 May;198:92-102
pubmed: 29524743
Arch Osteoporos. 2021 Feb 25;16(1):43
pubmed: 33634327
Biofizika. 1975 Jan-Feb;20(1):93-7
pubmed: 1111629
Fitoterapia. 2022 Mar;157:104981
pubmed: 34182052
Free Radic Biol Med. 2019 Jan;130:59-70
pubmed: 30359759
Int J Biol Macromol. 2021 Jul 31;183:1410-1418
pubmed: 34022306
Dig Dis Sci. 2019 Dec;64(12):3528-3538
pubmed: 31273592
Adv Clin Exp Med. 2018 Dec;27(12):1717-1722
pubmed: 30277667
J Clin Invest. 1990 Mar;85(3):632-9
pubmed: 2312718
PLoS One. 2019 Aug 7;14(8):e0220653
pubmed: 31390373
J Biomed Sci. 2015 Oct 29;22:101
pubmed: 26511009
Climacteric. 2022 Feb;25(1):81-87
pubmed: 34423690
Front Pharmacol. 2020 May 19;11:667
pubmed: 32508637
Biomed Pharmacother. 2020 Aug;128:110305
pubmed: 32485573
J Cell Mol Med. 2021 Nov;25(22):10454-10465
pubmed: 34626080
J Trace Elem Electrolytes Health Dis. 1992 Sep;6(3):137-51
pubmed: 1483033