LINC00520: A Potential Diagnostic and Prognostic Biomarker in Cancer.

Gene Expression Regulation, Neoplastic Head and Neck Neoplasms / genetics Humans Prognosis RNA, Long Noncoding / genetics Squamous Cell Carcinoma of Head and Neck / genetics
JAK/STAT LINC00520 P13K/AKT ceRNA prognosis transcription factor

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 29 12 2021
accepted: 15 02 2022
entrez: 21 3 2022
pubmed: 22 3 2022
medline: 3 5 2022
Statut: epublish

Résumé

Long non-coding RNA (lncRNA) is important in the study of cancer mechanisms. LINC00520 is located on human chromosome 14q22.3 and is a highly conserved long non-coding RNA. LINC00520 is widely expressed in various tissues. The expression of LINC00520 is regulated by transcription factors such as Sp1, TFAP4, and STAT3. The high expression of LINC00520 is significantly related to the risk of 11 cancers. LINC00520 can competitively bind 10 miRNAs to promote tumor cell proliferation, invasion, and migration. In addition, LINC00520 is involved in the regulation of P13K/AKT and JAK/STAT signaling pathways. The expression of LINC00520 is significantly related to the clinicopathological characteristics and prognosis of tumor patients and is also related to the sensitivity of HNSCC to radiotherapy. Here, this article summarizes the abnormal expression pattern of LINC00520 in cancer and its potential molecular regulation mechanism and points out that LINC00520 can be used as a potential biomarker for cancer diagnosis, prognosis, and treatment.

Identifiants

DOI: 10.3389/fimmu.2022.845418 PMID: 35309319 PMC: PMC8924041
pubmed: 35309319
doi: 10.3389/fimmu.2022.845418
pmc: PMC8924041
doi:

Substances chimiques

RNA, Long Noncoding 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

845418

Informations de copyright

Copyright © 2022 Zhang, Shen, Wu, Ruan, Zhu and Duan.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Qiudan Zhang (Q)

School of Medicine, Zhejiang University City College, Hangzhou, China.
Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.

Jinze Shen (J)

School of Medicine, Zhejiang University City College, Hangzhou, China.

Yuchen Wu (Y)

Department of Clinical Medicine, The First School of Medicine, Wenzhou Medical University, Wenzhou, China.

Wenjing Ruan (W)

Department of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Feng Zhu (F)

School of Medicine, Zhejiang University City College, Hangzhou, China.

Shiwei Duan (S)

School of Medicine, Zhejiang University City College, Hangzhou, China.
Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › LINC00520: A Potential Diagnostic and...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › LINC00520: A Potential Diagnostic and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › LINC00520: A Potential Diagnostic and...
questionsmedicales.fr › Diagnostic › Pronostic › LINC00520: A Potential Diagnostic and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › LINC00520: A Potential Diagnostic and...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › LINC00520: A Potential Diagnostic and...