Customized Hydrogel for Sustained Release of Highly Water-Soluble Drugs.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
15 Mar 2022
15 Mar 2022
Historique:
received:
31
10
2021
accepted:
27
01
2022
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
Highly water-soluble drugs, due to the rapid diffusion in water, are difficult to be released sustainably. To address the issue, a hydrogel with a core-shell structure is designed for the release of highly water-soluble drugs. The core is used to load the drug and the shell is devoted to isolating the drug from the release medium, which can decrease the drug concentration gradient and the driving force of drug release. The core-shell structure prolongs the drug release time by extending the drug release pathway. Moreover, the core-shell hydrogel possesses high swelling properties to reside in the stomach. The results demonstrate that the customized hydrogel can prolong the release of the highly water-soluble drug (metformin hydrochloride) for more than 50 h and alleviate the burst release of the drug.
Identifiants
pubmed: 35309415
doi: 10.1021/acsomega.1c06106
pmc: PMC8928546
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8493-8497Informations de copyright
© 2022 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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