DOT1L affects colorectal carcinogenesis via altering T cell subsets and oncogenic pathway.
DOT1L
FOXP3
H3K79me2
RORgt
Th17 cell
Th22 cell
colorectal cancer
regulatory T cell
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Chronic inflammation and oncogenic pathway activation are key-contributing factors in colorectal cancer pathogenesis. However, colorectal intrinsic mechanisms linking these two factors in cancer development are poorly defined. Here, we show that intestinal epithelial cell (IEC)-specific deletion of
Identifiants
pubmed: 35309733
doi: 10.1080/2162402X.2022.2052640
pii: 2052640
pmc: PMC8928792
doi:
Substances chimiques
Forkhead Transcription Factors
0
beta Catenin
0
DOT1L protein, human
EC 2.1.1.-
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2052640Informations de copyright
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
Déclaration de conflit d'intérêts
No potential conflict of interest was reported by the author(s).
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