Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age.
7 Tesla
Alzheimer’s disease
episodic memory
hippocampus subfield segmentation
iron
prodromal AD
subiculum
ultra-high field MRI
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
11
2021
accepted:
31
01
2022
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
Hippocampal atrophy is an established Alzheimer's Disease (AD) biomarker. Volume loss in specific subregions as measurable with ultra-high field magnetic resonance imaging (MRI) may reflect earliest pathological alterations. Data from positron emission tomography (PET) for estimation of cortical amyloid β (Aβ) and high-resolution 7 Tesla T1 MRI for assessment of hippocampal subfield volumes were analyzed in 61 non-demented elderly individuals who were divided into risk-categories as defined by high levels of cortical Aβ and low performance in standardized episodic memory tasks. High cortical Aβ and low episodic memory interactively predicted subicular volume [ Our results suggest that low subicular volume is linked to established indicators of AD risk, such as increased cortical Aβ and low episodic memory. Our data support subicular volume as a marker of dementia-risk susceptibility in old-aged non-demented persons.
Identifiants
pubmed: 35309894
doi: 10.3389/fnagi.2022.811146
pmc: PMC8926841
doi:
Types de publication
Journal Article
Langues
eng
Pagination
811146Informations de copyright
Copyright © 2022 Kagerer, Schroeder, van Bergen, Schreiner, Meyer, Steininger, Vionnet, Gietl, Treyer, Buck, Pruessmann, Hock and Unschuld.
Déclaration de conflit d'intérêts
CH is an employee and a shareholder of Neurimmune. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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