Merging the exposome into an integrated framework for "omics" sciences.
Environmental health
Exposure assessment
Omics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Mar 2022
18 Mar 2022
Historique:
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
The exposome concept encourages holistic consideration of the non-genetic factors (environmental exposures including lifestyle) that influence an individual's health over their life course. However, disconnect between the concept and practical application has promoted divergent interpretations of the exposome across disciplines and reinforced separation of the environmental (emphasizing exposures) and biological (emphasizing responses) research communities. In particular, while knowledge of biological responses can help to distinguish actual (i.e. experienced) from potential exposures, the inclusion of endogenous processes has generated confusion about the position of the exposome in a multi-omics systems biology context. We propose a reattribution of "exposome" to exclusively represent the totality of contact with external factors that a biological entity experiences, and introduce the term "functional exposomics" to denote the systematic study of exposure-phenotype interaction. This reoriented definition of the exposome allows a more readily integrable dataset for multi-omics and systems biology research.
Identifiants
pubmed: 35310334
doi: 10.1016/j.isci.2022.103976
pii: S2589-0042(22)00246-2
pmc: PMC8924626
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
103976Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
Dr. Miller receives royalties for his books The Exposome: A Primer and The Exposome: A New Paradigm for the Environment and Health. He has no other conflicts of interest. The other authors declare they have no actual or potential competing financial interests.
Références
Arch Toxicol. 2020 Feb;94(2):371-388
pubmed: 32034435
ALTEX. 2020;37(1):3-23
pubmed: 31960937
Environ Int. 2021 Nov;156:106630
pubmed: 34004450
Stat Med. 2016 May 20;35(11):1749-62
pubmed: 26646432
Environ Int. 2017 Feb;99:97-106
pubmed: 27939949
Bioinformatics. 2020 Mar 1;36(6):1785-1794
pubmed: 31693075
Int J Environ Res Public Health. 2020 Apr 22;17(8):
pubmed: 32331256
Epidemiology. 2017 May;28(3):399-402
pubmed: 28166102
Int J Environ Res Public Health. 2014 Dec 11;11(12):12866-95
pubmed: 25514145
Chem Res Toxicol. 2020 Aug 17;33(8):2010-2021
pubmed: 32672951
Cell. 2019 Mar 21;177(1):38-44
pubmed: 30901546
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23235-23241
pubmed: 32967067
PLoS One. 2019 Mar 7;14(3):e0213249
pubmed: 30845162
J Expo Anal Environ Epidemiol. 2005 Jan;15(1):1-5
pubmed: 15562291
Sci Data. 2022 Jan 20;9(1):10
pubmed: 35058476
Cell. 2021 Mar 18;184(6):1455-1468
pubmed: 33657411
Environ Mol Mutagen. 2013 Aug;54(7):596-8
pubmed: 23444186
Environ Sociol. 2017;3(2):107-121
pubmed: 28944245
Int J Epidemiol. 2012 Feb;41(1):24-32
pubmed: 22296988
Horm Behav. 2003 Jan;43(1):2-15
pubmed: 12614627
JAMA. 2006 Jul 12;296(2):212-5
pubmed: 16835427
J Epidemiol Community Health. 2012 Feb;66(2):103-5
pubmed: 22080817
DNA Repair (Amst). 2014 Jul;19:3-13
pubmed: 24767943
Nature. 2021 Apr;592(7856):695-703
pubmed: 33911272
Med Res Rev. 2022 Jan;42(1):441-461
pubmed: 34346083
Monogr Soc Res Child Dev. 2012 Jun;77(2):79-86
pubmed: 25242827
Int J Environ Res Public Health. 2005 Apr;2(1):4-9
pubmed: 16705795
Int J Environ Res Public Health. 2021 Jul 06;18(14):
pubmed: 34299672
Trends Ecol Evol. 2021 May;36(5):402-410
pubmed: 33583600
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18753-60
pubmed: 24218556
Environ Int. 2019 Sep;130:104877
pubmed: 31200158
Environ Sci Technol. 2017 Jan 3;51(1):616-624
pubmed: 27976870
Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13847-13855
pubmed: 31221749
Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:107-127
pubmed: 30095351
NeuroRx. 2004 Apr;1(2):182-8
pubmed: 15717018
Psychoneuroendocrinology. 2019 Oct;108:94-101
pubmed: 31252304
Nat Rev Drug Discov. 2003 Aug;2(8):668-76
pubmed: 12904817
BMC Med Res Methodol. 2021 Nov 27;21(1):266
pubmed: 34837966
Theor Appl Genet. 2016 Apr;129(4):653-673
pubmed: 26932121
Extrem Physiol Med. 2012 Oct 09;1(1):7
pubmed: 23849435
Public Health Rep. 2014 Jan-Feb;129 Suppl 2:19-31
pubmed: 24385661
Lancet. 2017 Mar 25;389(10075):1229-1237
pubmed: 28159391
Environ Sci Technol. 2017 Mar 7;51(5):3084-3092
pubmed: 28177231
Environ Sci Technol. 2021 Mar 2;55(5):2790-2799
pubmed: 33417434
Epidemiol Rev. 1995;17(1):240-2
pubmed: 8521943
Bioessays. 2020 Nov;42(11):e2000017
pubmed: 32851694
Mutagenesis. 2015 Nov;30(6):755-62
pubmed: 26290610
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50
pubmed: 16103423
BMC Syst Biol. 2011 Jun 06;5:92
pubmed: 21645360
J Physiol Anthropol. 2018 Jun 4;37(1):15
pubmed: 29866162
Methods Mol Biol. 2011;719:173-96
pubmed: 21370084
Environ Toxicol Chem. 2022 Jan;41(1):30-45
pubmed: 34714945
Environ Health Perspect. 2021 Aug;129(8):85001
pubmed: 34435882
Front Psychol. 2020 Apr 16;11:470
pubmed: 32372993
Trends Pharmacol Sci. 2019 Oct;40(10):763-773
pubmed: 31511194
Science. 2010 Oct 22;330(6003):460-1
pubmed: 20966241
Lancet. 2013 Jan 5;381(9860):3-4
pubmed: 23290956
Addict Biol. 2010 Apr;15(2):200-16
pubmed: 20148780
N Engl J Med. 2005 Oct 27;353(17):1848-50
pubmed: 16251542
Toxicol Sci. 2014 Jan;137(1):1-2
pubmed: 24213143
J Expo Sci Environ Epidemiol. 2011 Jan-Feb;21(1):5-9
pubmed: 21081972
J Theor Biol. 1997 May 7;186(1):55-63
pubmed: 9176637
Reprod Toxicol. 2020 Mar;92:57-65
pubmed: 31299210
Innovation (N Y). 2021 Oct 06;2(4):100172
pubmed: 34746906
Med Health Care Philos. 2009 Aug;12(3):235-44
pubmed: 19107577
NPJ Syst Biol Appl. 2020 Jul 16;6(1):22
pubmed: 32678105
Expert Rev Mol Diagn. 2006 Nov;6(6):891-902
pubmed: 17140376
J Human Stress. 1975 Jun;1(2):37-44
pubmed: 1235113
Science. 2020 Jan 24;367(6476):392-396
pubmed: 31974245
Elife. 2021 Jun 07;10:
pubmed: 34096867
Nucleic Acids Res. 2022 Mar 21;50(5):e27
pubmed: 34883510
Environ Health Perspect. 2016 Oct;124(10):1504-1510
pubmed: 27258438
J Human Stress. 1975 Mar;1(1):6-12 contd
pubmed: 798012
Bioessays. 2019 Jun;41(6):e1900014
pubmed: 31087675
Toxicol Sci. 2022 Feb 28;186(1):1-11
pubmed: 34878125