Dot6/Tod6 degradation fine-tunes the repression of ribosome biogenesis under nutrient-limited conditions.
Cell biology
Molecular biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Mar 2022
18 Mar 2022
Historique:
received:
25
06
2021
revised:
31
01
2022
accepted:
24
02
2022
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
Ribosome biogenesis (Ribi) is a complex and energy-consuming process, and should therefore be repressed under nutrient-limited conditions to minimize unnecessary cellular energy consumption. In yeast, the transcriptional repressors Dot6 and Tod6 are phosphorylated and inactivated by the TORC1 pathway under nutrient-rich conditions, but are activated and repress ∼200 Ribi genes under nutrient-limited conditions. However, we show that in the presence of rapamycin or under nitrogen starvation conditions, Dot6 and Tod6 were readily degraded by the proteasome in a SCF
Identifiants
pubmed: 35310337
doi: 10.1016/j.isci.2022.103986
pii: S2589-0042(22)00256-5
pmc: PMC8924686
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103986Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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