Neutrophilic Dermatoses: a Clinical Update.
Acute febrile neutrophilic dermatosis
Behçet disease
Neutrophilic dermatosis
Neutrophilic eccrine hidradenitis
Pyoderma gangrenosum
Sweet syndrome
Journal
Current dermatology reports
ISSN: 2162-4933
Titre abrégé: Curr Dermatol Rep
Pays: United States
ID NLM: 101599509
Informations de publication
Date de publication:
2022
2022
Historique:
accepted:
15
02
2022
pubmed:
22
3
2022
medline:
22
3
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
Neutrophilic dermatoses are defined by the presence of a sterile neutrophilic infiltrate on histopathology. This review focuses on the pathogenesis, epidemiology, clinicopathological features, diagnosis, and management of four disorders: Sweet syndrome, pyoderma gangrenosum, Behçet syndrome, and neutrophilic eccrine hidradenitis. Recent studies have provided insight into the complex pathogenesis of neutrophilic dermatoses. Evidence supports an intricate interplay of abnormal neutrophil function and inflammasome activation, malignant transformation into dermal infiltrating neutrophils, and genetic predisposition. Neutrophilic dermatoses have diverse cutaneous and extracutaneous manifestations and may be associated with significant morbidity and mortality. Common underlying associations include infectious, inflammatory, and neoplastic disorders, as well as drug reactions. Emerging diagnostic and therapeutic frameworks identify an expanding role for biologic and targeted anti-inflammatory therapies.
Identifiants
pubmed: 35310367
doi: 10.1007/s13671-022-00355-8
pii: 355
pmc: PMC8924564
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
89-102Informations de copyright
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.
Déclaration de conflit d'intérêts
Conflict of InterestThe authors have no relevant financial or non-financial interests to disclose. Dr. Mostaghimi reports grants and personal fees from Pfizer, personal fees and other from Concert, personal fees and other from Lilly, personal fees from AbbVie, personal fees from ACON Labs, personal fees from Bioniz, personal fees from hims and hers, and personal fees from Digital Diagnostics, outside the submitted work. Dr. Rosenbach reports personal fees from Merck, personal fees from Janssen, personal fees from Novartis, personal fees from Eli Lilly, and grants and personal fees from Processa, outside the submitted work.
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