Early Alzheimer's disease-like reductions in gray matter and cognitive function with aging in nonhuman primates.
Alzheimer's disease
magnetic resonance imaging
non‐human primate
vervet
working memory
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
12
2021
revised:
24
12
2021
accepted:
15
02
2022
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
Age-related neuropathology associated with sporadic Alzheimer's disease (AD) often develops well before the onset of symptoms. Given AD's long preclinical period, translational models are needed to identify early signatures of pathological decline. Using structural magnetic resonance imaging and cognitive assessments, we examined the relationships among age, cognitive performance, and neuroanatomy in 48 vervet monkeys ( We found negative associations of age with cortical gray matter volume ( Cortical gray matter diminishes with age in vervets in regions relevant to AD, which may increase risk of cognitive impairment. This study lays the groundwork for future investigations to test therapeutics to delay or slow pathological decline.
Identifiants
pubmed: 35310523
doi: 10.1002/trc2.12284
pii: TRC212284
pmc: PMC8918111
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12284Subventions
Organisme : NIA NIH HHS
ID : L30 AG074138
Pays : United States
Organisme : NIH HHS
ID : P40 OD010965
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG033534
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NIA NIH HHS
ID : R24 AG073199
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072947
Pays : United States
Informations de copyright
© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
THe authors declare no conflicts of interest.
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