Effect of a Hemodialysis Session on Markers of Inflammation and Endotoxin.
Journal
International journal of inflammation
ISSN: 2090-8040
Titre abrégé: Int J Inflam
Pays: United States
ID NLM: 101538188
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
12
2021
accepted:
12
02
2022
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
22
3
2022
Statut:
epublish
Résumé
People receiving hemodialysis (HD) treatment have higher cardiovascular morbidity and mortality, ascribed to an increased prevalence of traditional cardiovascular risk factors. However, the role of nontraditional risk factors, such as inflammation, has become increasingly recognized. The origin of this inflammation remains elusive and one putative cause is elevated levels of circulating bacterial endotoxin. In this study, serum concentrations of endotoxin and inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), interleukin-1 Endotoxin was detectable in only 1 of 90 samples analyzed. There were no significant differences in serum hsCRP, IL1
Sections du résumé
Background
UNASSIGNED
People receiving hemodialysis (HD) treatment have higher cardiovascular morbidity and mortality, ascribed to an increased prevalence of traditional cardiovascular risk factors. However, the role of nontraditional risk factors, such as inflammation, has become increasingly recognized. The origin of this inflammation remains elusive and one putative cause is elevated levels of circulating bacterial endotoxin.
Methods
UNASSIGNED
In this study, serum concentrations of endotoxin and inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), interleukin-1
Results
UNASSIGNED
Endotoxin was detectable in only 1 of 90 samples analyzed. There were no significant differences in serum hsCRP, IL1
Identifiants
pubmed: 35310812
doi: 10.1155/2022/8632245
pmc: PMC8930269
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8632245Informations de copyright
Copyright © 2022 Shyam Dheda et al.
Déclaration de conflit d'intérêts
DJ has received consultancy fees, research funds, speaker's honoraria, and travel sponsorships from Baxter Healthcare and Fresenius Medical Care, as well as consultancy fees from Astra Zeneca, Bayer, and AWAK, speaker's honoraria from Ono and BI & Lilly, and travel sponsorships from Amgen. He is currently a recipient of an Australian National Health and Medical Research Council Leadership Investigator Grant. CH has received research support from Baxter Healthcare and Fresenius medical Care. SD, DV and MF have no conflicts of interest to declare.
Références
Nephrol Dial Transplant. 2006 Aug;21(8):2057-60
pubmed: 16762961
Int Rev Immunol. 2017 May 4;36(3):125-144
pubmed: 28783409
Am J Kidney Dis. 2011 Jul;58(1):64-72
pubmed: 21458896
J Am Soc Nephrol. 2006 Dec;17(12 Suppl 3):S274-80
pubmed: 17130274
Int Urol Nephrol. 2001;33(2):207-15
pubmed: 12092633
PLoS One. 2016 Oct 20;11(10):e0164978
pubmed: 27764208
Kidney Int. 1999 Feb;55(2):648-58
pubmed: 9987089
J Lipid Res. 2015 Jul;56(7):1363-9
pubmed: 26023073
Am J Kidney Dis. 2002 Dec;40(6):1230-9
pubmed: 12460042
Arch Dis Child Educ Pract Ed. 2019 Jun;104(3):150-153
pubmed: 30026267
Nephrol Dial Transplant. 2014 Feb;29(2):414-22
pubmed: 24235073
Nephron. 1990;56(1):44-9
pubmed: 2234248
Nephrol Dial Transplant. 2010 Nov;25(11):3717-23
pubmed: 20484301
Hemodial Int. 2007 Jan;11(1):1-14
pubmed: 17257349
Am J Med. 2001 Feb 15;110(3):198-204
pubmed: 11182106
Hemodial Int. 2013 Jul;17(3):359-65
pubmed: 23231033
Clin Nephrol. 2016 Supplement 1;86 (2016)(13):131-135
pubmed: 27509588
Clin J Am Soc Nephrol. 2011 Jan;6(1):133-41
pubmed: 20876680
J Am Soc Nephrol. 2002 Jan;13 Suppl 1:S28-36
pubmed: 11792759
Kidney Blood Press Res. 2019;44(5):907-914
pubmed: 31505506
J Am Soc Nephrol. 2004 Nov;15(11):2916-22
pubmed: 15504945
Crit Rev Clin Lab Sci. 2016;53(3):197-215
pubmed: 26732012
Diagnosis (Berl). 2020 Apr 17;8(2):249-256
pubmed: 32304297
Nephrol Dial Transplant. 2018 Oct 1;33(suppl_3):iii35-iii40
pubmed: 30281126
Hemodial Int. 2013 Jan;17(1):59-66
pubmed: 22716238
Acta Med Indones. 2004 Apr-Jun;36(2):93-6
pubmed: 15931701
J Endocr Soc. 2020 Feb 20;4(2):bvz039
pubmed: 32099951