Long-term eltrombopag for bone marrow failure depletes iron.
Journal
American journal of hematology
ISSN: 1096-8652
Titre abrégé: Am J Hematol
Pays: United States
ID NLM: 7610369
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
revised:
16
03
2022
received:
07
02
2022
accepted:
17
03
2022
pubmed:
22
3
2022
medline:
6
5
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
Eltrombopag (EPAG) has been approved for the treatment of aplastic anemia and for immune thrombocytopenia, and a subset of patients require long-term therapy. Due to polyvalent cation chelation, prolonged therapy leads to previously underappreciated iron depletion. We conducted a retrospective review of patients treated at the NIH for aplastic anemia, myelodysplastic syndrome, and unilineage cytopenias, comparing those treated with EPAG to a historical cohort treated with immunosuppression without EPAG. We examined iron parameters, duration of therapy, response assessment, relapse rates, and common demographic parameters. We included 521 subjects treated with (n = 315) or without EPAG (n = 206) across 11 studies with multiyear follow-up (3.6 vs. 8.5 years, respectively). Duration of EPAG exposure correlated with ferritin reduction (p = 4 × 10
Identifiants
pubmed: 35312200
doi: 10.1002/ajh.26543
pmc: PMC9081201
mid: NIHMS1790479
doi:
Substances chimiques
Benzoates
0
Hydrazines
0
Pyrazoles
0
Ferritins
9007-73-2
Iron
E1UOL152H7
eltrombopag
S56D65XJ9G
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
791-801Subventions
Organisme : Intramural NIH HHS
ID : ZIA HL006186
Pays : United States
Informations de copyright
Published 2022. This article is a U.S. Government work and is in the public domain in the USA.
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