Europium-Doped Cerium Oxide Nanoparticles for Microglial Amyloid Beta Clearance and Homeostasis.

Alzheimer Disease / drug therapy Amyloid beta-Peptides / metabolism Animals Cerium Europium / metabolism Homeostasis Mice Mice, Transgenic Microglia / metabolism Nanoparticles Plaque, Amyloid / metabolism
Alzheimer’s disease (AD) BV2 cells and immune modulation amyloid beta (Aβ) cerium oxide europium-doped cerium oxide nanoparticles (EuCeO2NPs) microglia

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
20 04 2022
Historique:
pubmed: 22 3 2022
medline: 22 4 2022
entrez: 21 3 2022
Statut: ppublish

Résumé

Alzheimer's disease (AD) is the most common neurodegenerative disorder. Pathologically, the disease is characterized by the deposition of amyloid beta (Aβ) plaques and the presence of neurofibrillary tangles. These drive microglia neuroinflammation and consequent neurodegeneration. While the means to affect Aβ plaque accumulation pharmacologically was achieved, how it affects disease outcomes remains uncertain. Cerium oxide (CeO

Identifiants

DOI: 10.1021/acschemneuro.1c00847 PMID: 35312284 PMC: PMC9227977
pubmed: 35312284
doi: 10.1021/acschemneuro.1c00847
pmc: PMC9227977
mid: NIHMS1809160
doi:

Substances chimiques

Amyloid beta-Peptides 0
Cerium 30K4522N6T
Europium 444W947O8O
ceric oxide 619G5K328Y

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1232-1244

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS036126
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145542
Pays : United States
Organisme : NIDA NIH HHS
ID : P01 DA028555
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062261
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM113126
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA050540
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121402
Pays : United States
Organisme : NIMH NIH HHS
ID : P01 MH064570
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043540
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034239
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115860
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS043985
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI158160
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS031492
Pays : United States

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Auteurs

Jatin Machhi (J)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Pravin Yeapuri (P)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Milica Markovic (M)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Milankumar Patel (M)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Wenhui Yan (W)

Department of Pharmacology, School of Basic Medical Science, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China.

Yaman Lu (Y)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Jacob D Cohen (JD)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Mahmudul Hasan (M)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Mai Mohamed Abdelmoaty (MM)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza 12622, Egypt.

You Zhou (Y)

Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.

Huangui Xiong (H)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Xinglong Wang (X)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

R Lee Mosley (RL)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Howard E Gendelman (HE)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
ORCID: 0000-0002-7831-0370

Bhavesh D Kevadiya (BD)

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
ORCID: 0000-0002-9119-7798

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Europium-Doped Cerium Oxide Nanoparticles for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Europium-Doped Cerium Oxide Nanoparticles for...
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