Spherical nucleic acids as an infectious disease vaccine platform.
antiviral vaccines
infectious disease
rational vaccinology
spherical nucleic acids
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
05 04 2022
05 04 2022
Historique:
entrez:
21
3
2022
pubmed:
22
3
2022
medline:
2
4
2022
Statut:
ppublish
Résumé
SignificanceUsing SARS-CoV-2 as a relevant case study for infectious disease, we investigate the structure-function relationships that dictate antiviral spherical nucleic acid (SNA) vaccine efficacy. We show that the SNA architecture can be rapidly employed to target COVID-19 through incorporation of the receptor-binding domain, and that the resulting vaccine potently activates human cells in vitro and mice in vivo. Furthermore, when challenged with a lethal viral infection, only mice treated with the SNA vaccine survived. Taken together, this work underscores the importance of rational vaccine design for infectious disease to yield vaccines that elicit more potent immune responses to effectively fight disease.
Identifiants
pubmed: 35312341
doi: 10.1073/pnas.2119093119
pmc: PMC9168922
doi:
Substances chimiques
Nucleic Acids
0
Vaccines, DNA
0
Viral Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2119093119Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM108569
Pays : United States
Organisme : NU | Robert H. Lurie Comprehensive Cancer Center (LCC)
ID : S10OD025194
Organisme : HHS | NIH | National Cancer Institute (NCI)
ID : CCSG P30 CA060553
Organisme : Recombinant Protein Production Core
ID : N/A
Organisme : HHS | NIH | National Cancer Institute (NCI)
ID : P50CA221747
Organisme : National Science Foundation (NSF)
ID : ECCS-2025633
Organisme : HHS | National Institutes of Health (NIH)
ID : T32CA186897
Organisme : HHS | NIH | National Cancer Institute (NCI)
ID : R01CA208783
Organisme : DOD | USAF | AFMC | Air Force Office of Scientific Research (AFOSR)
ID : FA9550-17-1-0348
Organisme : NCI NIH HHS
ID : P50 CA221747
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA208783
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA186897
Pays : United States
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