Antioxidant role of selenium against maneb-induced cardiotoxicity in mice.
Cardiotoxicity
Fatty acids
Lipid profile
Maneb
Oxidative stress
Selenium
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
03
09
2021
accepted:
24
02
2022
pubmed:
22
3
2022
medline:
10
8
2022
entrez:
21
3
2022
Statut:
ppublish
Résumé
The current study was conducted to assess the beneficial effect of selenium (Se) on maneb-induced cardiotoxicity and fatty acid alterations in adult mice. Swiss albino male mice were assigned into four experimental groups. The first group consisted of negative controls. The second group represented the positive controls where mice received daily, via the diet, sodium selenite at a dose of 0.2 mg/kg. For the third group, mice were subjected to intraperitoneal injections of maneb (30 mg/kg BW). The fourth group (MB+Se) received daily the same dose of maneb as group 3 along with sodium selenite at the same dose as group 2. Mice exposure to maneb caused cardiotoxicity as indicated by an increase in malondialdehyde, hydrogen peroxide, and protein carbonyl levels, and an alteration of the antioxidant defense system (catalase, glutathione peroxidase, superoxide dismutase, glutathione, and vitamin C). Plasma lactate dehydrogenase activity and total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels increased, while high-density lipoprotein cholesterol level decreased. Results showed also a decrease in the amount of n-3 PUFA, docosahexaenoic, docosapentaenoic, and eicosapentaenoic acids. However, an increase in the levels of MUFA, cis-vaccenic, and palmitoleic acids was observed. Co-administration of Se restored the parameters indicated above to near control values. The histopathological findings confirmed the biochemical results. Selenium could be a useful and efficient agent against maneb-induced cardiotoxicity.
Identifiants
pubmed: 35312919
doi: 10.1007/s11356-022-19497-0
pii: 10.1007/s11356-022-19497-0
doi:
Substances chimiques
Antioxidants
0
Maneb
12427-38-2
Cholesterol
97C5T2UQ7J
Superoxide Dismutase
EC 1.15.1.1
Selenium
H6241UJ22B
Sodium Selenite
HIW548RQ3W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
54827-54841Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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