Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death.

Animals Cell Death / genetics Cell Respiration / genetics Cells, Cultured Cytoprotection / genetics Dopaminergic Neurons / physiology Dual-Specificity Phosphatases / physiology HEK293 Cells Humans Male Mice Mice, 129 Strain Mice, Knockout Mitochondria / genetics Mitogen-Activated Protein Kinase Phosphatases / physiology Neurodegenerative Diseases / genetics Oxidative Stress / genetics Parkinson Disease / genetics
Dopaminergic neurons Dusp26 LRRK2 Mouse model Neurodegeneration p38

Journal

Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402

Informations de publication

Date de publication:
21 Mar 2022
Historique:
received: 19 10 2021
accepted: 21 01 2022
revised: 04 01 2022
entrez: 21 3 2022
pubmed: 22 3 2022
medline: 25 3 2022
Statut: epublish

Résumé

The dual specificity protein phosphatases (Dusps) control dephosphorylation of mitogen-activated protein kinases (MAPKs) as well as other substrates. Here, we report that Dusp26, which is highly expressed in neuroblastoma cells and primary neurons is targeted to the mitochondrial outer membrane via its NH

Identifiants

DOI: 10.1007/s00018-022-04162-z PMID: 35313355 PMC: PMC10601927
pubmed: 35313355
doi: 10.1007/s00018-022-04162-z
pii: 10.1007/s00018-022-04162-z
pmc: PMC10601927
mid: NIHMS1938948
doi:

Substances chimiques

Mitogen-Activated Protein Kinase Phosphatases EC 3.1.3.16
DUSP26 protein, human EC 3.1.3.48
Dual-Specificity Phosphatases EC 3.1.3.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

198

Subventions

Organisme : BLRD VA
ID : I01 BX000161
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA062130
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA132640
Pays : United States
Organisme : NCI NIH HHS
ID : CA062130
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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Auteurs

Binnur Eroglu (B)

Molecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA.

Xiongjie Jin (X)

Molecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA.

Sadiki Deane (S)

Molecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA.
Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.

Bahadır Öztürk (B)

Molecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA.
Medical Biochemistry Department, Selcuk University Medical Faculty, Konya, Turkey.

Owen A Ross (OA)

Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL, 32224, USA.

Demetrius Moskophidis (D)

Molecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA. dmoskofidis@augusta.edu.
Department of Medicine, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA. dmoskofidis@augusta.edu.

Nahid F Mivechi (NF)

Molecular Chaperone Biology, Georgia Cancer Center, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA. nmivechi@augusta.edu.
Departments of Radiation Oncology, Medical College of Georgia at Augusta University, 1120 15th St., CN3153, Augusta, GA, 30912, USA. nmivechi@augusta.edu.
Charlie Norwood VAMC, One Freedom Way, Augusta, GA, 30904, USA. nmivechi@augusta.edu.
ORCID: 0000-0002-3510-9968

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Cellules › Cellules cultivées › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Cytoprotection › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Dual-specificity phosphatases › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Souris de souche-129 › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Mitogen-Activated Protein Kinase Phosphatases › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Dusp26 phosphatase regulates mitochondrial...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Dusp26 phosphatase regulates mitochondrial...