Evaluation of anti-gastric ulcer activity of aqueous and 80% methanol leaf extracts of
Ethanol
Gastric ulcer
Indomethacin
Pylorus ligation
Urtica simensis
Journal
Metabolism open
ISSN: 2589-9368
Titre abrégé: Metabol Open
Pays: England
ID NLM: 101767753
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
30
09
2021
revised:
28
02
2022
accepted:
01
03
2022
entrez:
22
3
2022
pubmed:
23
3
2022
medline:
23
3
2022
Statut:
epublish
Résumé
Gastric ulcer is a major public health problem globally and associated with severe complications including hemorrhages, perforations, gastrointestinal obstruction, and malignancy. The leaf extracts were prepared using decoction (aqueous) and maceration (80% methanol) techniques and in In pylorus ligation induced gastric ulcer model, both aqueous and 80% methanol extracts at doses of 200 and 400 mg/kg were exhibited significant reduction in total acidity, volume of gastric secretion (p < 0.001) and substansial rise in pH (p˂0.05) of the gastric secretion. In indomethacin induced ulcer model, both aqueous and methanol extracts were exhibited dose dependent increment in gastric wall mucus compared to control (p < 0.001). In ethanol induced ulcer model, all doses of extract produced significant increment in gastric wall mucus from 46.66 ± 0.96 (AQ100) to 75.87 ± 1.52 (ME 400) μg alcian blue/g wet stomach. Five days pre-treatment with 200 mg/kg of both and aqueous and methanolic extracts exhibited significant ( Both extracts of
Sections du résumé
Background
UNASSIGNED
Gastric ulcer is a major public health problem globally and associated with severe complications including hemorrhages, perforations, gastrointestinal obstruction, and malignancy.
Methods
UNASSIGNED
The leaf extracts were prepared using decoction (aqueous) and maceration (80% methanol) techniques and in
Results
UNASSIGNED
In pylorus ligation induced gastric ulcer model, both aqueous and 80% methanol extracts at doses of 200 and 400 mg/kg were exhibited significant reduction in total acidity, volume of gastric secretion (p < 0.001) and substansial rise in pH (p˂0.05) of the gastric secretion. In indomethacin induced ulcer model, both aqueous and methanol extracts were exhibited dose dependent increment in gastric wall mucus compared to control (p < 0.001). In ethanol induced ulcer model, all doses of extract produced significant increment in gastric wall mucus from 46.66 ± 0.96 (AQ100) to 75.87 ± 1.52 (ME 400) μg alcian blue/g wet stomach. Five days pre-treatment with 200 mg/kg of both and aqueous and methanolic extracts exhibited significant (
Conclusion
UNASSIGNED
Both extracts of
Identifiants
pubmed: 35313530
doi: 10.1016/j.metop.2022.100172
pii: S2589-9368(22)00010-X
pmc: PMC8933831
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100172Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
J Ethnopharmacol. 2004 Feb;90(2-3):205-15
pubmed: 15013182
J Pharm Pharmacol. 2000 Sep;52(9):1157-62
pubmed: 11045898
Molecules. 2018 Jul 17;23(7):
pubmed: 30018251
Int J Mol Sci. 2012;13(3):3203-28
pubmed: 22489149
Pak J Pharm Sci. 2009 Oct;22(4):384-90
pubmed: 19783516
Phytother Res. 2000 Dec;14(8):581-91
pubmed: 11113992
J Exp Pharmacol. 2017 Jan 16;9:1-11
pubmed: 28144167
J Ethnopharmacol. 2010 Aug 19;131(1):17-21
pubmed: 20488236
J Ethnopharmacol. 2010 Mar 24;128(2):537-40
pubmed: 20083180
Phytomedicine. 2010 Jul;17(8-9):569-74
pubmed: 19962286
J Ethnopharmacol. 2007 Sep 25;113(3):433-40
pubmed: 17706386
Int Sch Res Notices. 2017 Jun 1;2017:8375398
pubmed: 28656171
Interdiscip Toxicol. 2018 May;11(1):5-12
pubmed: 30181707
Indian J Pharm Sci. 2011 Sep;73(5):572-7
pubmed: 22923872
J Ethnobiol Ethnomed. 2015 Jan 07;11:4
pubmed: 25572933
BMC Res Notes. 2017 Apr 18;10(1):157
pubmed: 28420410
J Ethnopharmacol. 2010 Feb 17;127(3):750-4
pubmed: 19963056
Nutrients. 2018 Jun 13;10(6):
pubmed: 29899291