Increased Risk of Acute Lymphoblastic Leukemia in Adult Patients with GSTM1 Null Genetic Polymorphism.

GSTM1 GSTT1 acute lymphoblastic leukemia polymorphism

Journal

Pharmacogenomics and personalized medicine
ISSN: 1178-7066
Titre abrégé: Pharmgenomics Pers Med
Pays: New Zealand
ID NLM: 101514107

Informations de publication

Date de publication:
2022
Historique:
received: 29 12 2021
accepted: 04 03 2022
entrez: 22 3 2022
pubmed: 23 3 2022
medline: 23 3 2022
Statut: epublish

Résumé

Glutathione S-transferases (GSTT1 and GSTM1) detoxify various endogenous and exogenous compounds and provide cytoprotective role against reactive species. This study aimed to assess the frequency of This case-control study included 128 adult Sudanese, untreated newly diagnosed patients with ALL, aged 18 to 74 years and 128 age-gender matched healthy controls. Deletional polymorphisms of The genotypic frequency of Irrespective of age at diagnosis, gender, and phenotype of ALL, GSTM1 null polymorphism either alone or in combination with GSTT1 null polymorphism poses significantly increased risk of developing ALL in adults.

Identifiants

pubmed: 35313604
doi: 10.2147/PGPM.S356302
pii: 356302
pmc: PMC8934168
doi:

Types de publication

Journal Article

Langues

eng

Pagination

227-234

Informations de copyright

© 2022 Abdalhabib et al.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest in this work.

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Auteurs

Ezeldine K Abdalhabib (EK)

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al-Qurayyat, Saudi Arabia.

Badr Alzahrani (B)

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al-Qurayyat, Saudi Arabia.

Fehaid Alanazi (F)

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al-Qurayyat, Saudi Arabia.

Abdulrahman Algarni (A)

Department of Medical Laboratory Technology, College of Applied Medical Sciences, Northern Borders University, Arar, Saudi Arabia.

Ibrahim Khider Ibrahim (IK)

Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.

Hozifa A Mohamed (HA)

Department of Molecular Biology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.
Department of Molecular Biology, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum, Sudan.

Hassan A Hamali (HA)

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.

Abdullah A Mobarki (AA)

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.

Gasim Dobie (G)

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.

Muhammad Saboor (M)

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Medical Research Center (MRC), Jazan University, Jazan, Saudi Arabia.

Classifications MeSH