Solving neurodegeneration: common mechanisms and strategies for new treatments.
Alzheimer’s Disease
Biomarker
Cell-replacement
Detection
Genetics
Glaucoma
Glia
Huntington’s Disease
Imaging
Metabolic stress
Model Systems
Neuro-regeneration
Neuro-replacement
Neurodegeneration
Neurovascular coupling
Organoids
Parkinson’s Disease
Journal
Molecular neurodegeneration
ISSN: 1750-1326
Titre abrégé: Mol Neurodegener
Pays: England
ID NLM: 101266600
Informations de publication
Date de publication:
21 03 2022
21 03 2022
Historique:
received:
17
11
2021
accepted:
18
02
2022
entrez:
22
3
2022
pubmed:
23
3
2022
medline:
12
4
2022
Statut:
epublish
Résumé
Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled "Solving Neurodegeneration". This "think-tank" style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world's leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.
Identifiants
pubmed: 35313950
doi: 10.1186/s13024-022-00524-0
pii: 10.1186/s13024-022-00524-0
pmc: PMC8935795
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
23Subventions
Organisme : NEI NIH HHS
ID : P30 EY026877
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM127147
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS123912
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY030138
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG046205
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG069701
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY030218
Pays : United States
Organisme : NINDS NIH HHS
ID : K08 NS101118
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026942
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066395
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057181
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Front Neurol. 2021 May 26;12:651639
pubmed: 34122299
J Neurosci Methods. 2021 Sep 1;361:109281
pubmed: 34237384
Nat Med. 2021 Jun;27(6):954-963
pubmed: 34083813
Br J Ophthalmol. 2018 Feb;102(2):233-237
pubmed: 28600299
Annu Rev Neurosci. 2020 Jul 8;43:375-389
pubmed: 32640930
J Neurosci. 2008 Nov 12;28(46):12085-96
pubmed: 19005073
Front Neurol. 2021 Jun 09;12:681326
pubmed: 34177786
JAMA Neurol. 2021 Nov 1;78(11):1375-1382
pubmed: 34542571
Neurotherapeutics. 2011 Jul;8(3):361-73
pubmed: 21556678
Exp Eye Res. 2020 Feb;191:107900
pubmed: 31874142
JAMA Neurol. 2020 Sep 28;:
pubmed: 32986090
eNeuro. 2022 Feb 28;:
pubmed: 35228310
J Neurosci Res. 2019 Jan;97(1):70-76
pubmed: 29775216
Exp Neurol. 2017 Jan;287(Pt 3):365-373
pubmed: 26746987
Alzheimers Dement. 2016 Jan;12(1):60-4
pubmed: 26710325
Graefes Arch Clin Exp Ophthalmol. 1997 Oct;235(10):618-26
pubmed: 9349945
Arch Ophthalmol. 1968 Dec;80(6):696-702
pubmed: 4177355
Surv Ophthalmol. 1989 Mar-Apr;33(5):331-7
pubmed: 2655138
Neurology. 2003 May 13;60(9):1495-500
pubmed: 12743238
Eye (Lond). 2020 Jan;34(1):29-39
pubmed: 31645673
Ophthalmology. 1997 Nov;104(11):1926-33
pubmed: 9373128
Optom Vis Sci. 1999 Aug;76(8):537-43
pubmed: 10472959
PLoS One. 2013;8(2):e57557
pubmed: 23451242
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19587-92
pubmed: 19875691
Cells. 2020 Nov 04;9(11):
pubmed: 33158189
Arch Biochem Biophys. 2021 Apr 15;701:108815
pubmed: 33609537
Front Neurosci. 2019 Jun 04;13:521
pubmed: 31213970
Lancet Neurol. 2016 Jun;15(7):673-684
pubmed: 27068280
Ann Neurol. 2014 Apr;75(4):563-73
pubmed: 24623176
Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5309-14
pubmed: 14638731
Prog Retin Eye Res. 2021 Jul;83:100916
pubmed: 33075485
Annu Rev Vis Sci. 2020 Sep 15;6:195-213
pubmed: 32936739
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10190-5
pubmed: 21646527
Acta Ophthalmol. 2011 Nov;89(7):e544-9
pubmed: 21599872
Surv Ophthalmol. 1980 May-Jun;24(6):621-64
pubmed: 7414505
Nat Mater. 2021 Feb;20(2):145-155
pubmed: 33199860
Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):
pubmed: 22908195
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Clin Pharmacol Ther. 2001 Mar;69(3):89-95
pubmed: 11240971
Cell Tissue Res. 2013 Aug;353(2):339-45
pubmed: 23779255
Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):
pubmed: 35135877
Neuron. 1996 Mar;16(3):675-86
pubmed: 8785064
Neuron. 2020 Dec 9;108(5):801-821
pubmed: 33096024
J Med Genet. 1994 Apr;31(4):280-6
pubmed: 8071952
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Nat Neurosci. 2011 Oct 26;14(11):1398-1405
pubmed: 22030551
Nat Commun. 2020 Jul 27;11(1):3753
pubmed: 32719333
Lancet. 1993 Sep 18;342(8873):697-9
pubmed: 8103819
Nature. 2020 Sep;585(7823):91-95
pubmed: 32788726
Mol Neurodegener. 2021 Jul 21;16(1):49
pubmed: 34289882
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Neurobiol Dis. 2019 Jul;127:410-418
pubmed: 30923004
JAMA Neurol. 2019 Jul 1;76(7):791-799
pubmed: 31009028
Neuron. 2019 Dec 18;104(6):1039-1055.e12
pubmed: 31784286
Nat Neurosci. 2006 Jun;9(6):843-52
pubmed: 16699509
Brain Res. 2018 Nov 1;1698:179-186
pubmed: 30081037
Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):26-35
pubmed: 30601928
Sci Transl Med. 2020 Feb 5;12(529):
pubmed: 32024798
Front Cell Dev Biol. 2020 May 13;8:328
pubmed: 32528949
Surv Ophthalmol. 2018 May - Jun;63(3):296-306
pubmed: 28986311
Alzheimers Dement (N Y). 2018 Sep 06;4:575-590
pubmed: 30406177
Front Cell Dev Biol. 2020 Jun 16;8:452
pubmed: 32656207
Biomolecules. 2021 Apr 15;11(4):
pubmed: 33920974
Semin Ophthalmol. 2016;31(1-2):140-6
pubmed: 26959139
Sci Transl Med. 2020 Mar 25;12(536):
pubmed: 32213628
Nat Rev Neurol. 2020 Apr;16(4):199-212
pubmed: 32203399
Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2581-6
pubmed: 25675510
Nature. 2017 Sep 28;549(7673):523-527
pubmed: 28959956
JAMA Ophthalmol. 2018 Nov 1;136(11):1242-1248
pubmed: 30352114
Am J Ophthalmol. 2004 Sep;138(3 Suppl):S1-2
pubmed: 15364046
J Clin Invest. 2017 Dec 1;127(12):4403-4414
pubmed: 29106385
Can J Ophthalmol. 1976 Apr;11(2):102-5
pubmed: 1078325
Exp Eye Res. 2015 Apr;133:19-29
pubmed: 25819451
Mol Neurodegener. 2020 May 29;15(1):30
pubmed: 32471464
Nature. 2012 Aug 2;488(7409):96-9
pubmed: 22801501
Science. 2019 Jul 19;365(6450):223-224
pubmed: 31320524
Sci Transl Med. 2021 Sep 29;13(613):eabc9375
pubmed: 34586832
Arch Ophthalmol. 1999 Aug;117(8):1050-6
pubmed: 10448748
J Cell Biol. 2021 Jul 5;220(7):
pubmed: 34152362
Mov Disord. 2020 Dec;35(12):2230-2239
pubmed: 32960470
Mol Cell Neurosci. 2019 Jun;97:18-33
pubmed: 30529601
J Clin Invest. 2011 Apr;121(4):1429-44
pubmed: 21383504
Cell Mol Neurobiol. 2022 Jan;42(1):41-57
pubmed: 33040237
Hum Mol Genet. 2014 Nov 1;23(21):5838-46
pubmed: 24899047
Nat Rev Neurosci. 2004 May;5(5):347-60
pubmed: 15100718
J Neuroinflammation. 2019 Feb 21;16(1):46
pubmed: 30791945
Nat Immunol. 2017 Feb;18(2):123-131
pubmed: 28092374
Nat Med. 2020 Aug;26(8):1256-1263
pubmed: 32572268
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18810-18821
pubmed: 32690710
Nature. 2016 Aug 31;537(7618):50-6
pubmed: 27582220
Prog Retin Eye Res. 2020 Mar;75:100799
pubmed: 31557521
Mol Psychiatry. 2021 Jan;26(1):296-308
pubmed: 32251378
Acta Ophthalmol. 2019 May;97(3):e331-e340
pubmed: 30549197
J Neurosci. 2003 Mar 15;23(6):2284-93
pubmed: 12657687
Exp Eye Res. 2011 Aug;93(2):120-32
pubmed: 20849846
Invest Ophthalmol Vis Sci. 2005 May;46(5):1721-5
pubmed: 15851574
Glia. 2006 Nov 1;54(6):485-98
pubmed: 16906540
PLoS Med. 2018 Jan 9;15(1):e1002487
pubmed: 29315334
Alzheimers Res Ther. 2014 Jul 03;6(4):37
pubmed: 25024750
Int J Geriatr Psychiatry. 1998 Sep;13(9):625-30
pubmed: 9777427
Neuron. 2021 May 19;109(10):1657-1674.e7
pubmed: 33831349
Nature. 2010 Nov 11;468(7321):232-43
pubmed: 21068832
Nat Genet. 1997 Nov;17(3):263-4
pubmed: 9354781
Cell. 2021 Aug 19;184(17):4547-4563.e17
pubmed: 34314701
Stem Cell Reports. 2021 Jan 12;16(1):149-167
pubmed: 33382979
Front Immunol. 2018 May 16;9:1056
pubmed: 29868017
Ann Ophthalmol. 1980 Dec;12(12):1383
pubmed: 7224498
Ann Neurol. 2014 Jun;75(6):964-6
pubmed: 24816946
Prog Retin Eye Res. 2001 Sep;20(5):595-624
pubmed: 11470452
J Neurosci Res. 2001 Jun 1;64(5):523-32
pubmed: 11391707
J Neuropathol Exp Neurol. 2011 Jan;70(1):63-8
pubmed: 21157377
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Sep;1866(9):158980
pubmed: 34044125
Science. 2020 Oct 2;370(6512):61-66
pubmed: 33004512
N Engl J Med. 2013 Apr 4;368(14):1326-34
pubmed: 23550670
Front Neuroendocrinol. 2020 Jan;56:100804
pubmed: 31689419
Circ Res. 2018 Aug 3;123(4):406-408
pubmed: 30355253
Biomedicines. 2020 Dec 10;8(12):
pubmed: 33321831
Invest Ophthalmol Vis Sci. 1986 Dec;27(12):1706-12
pubmed: 2947873
Br J Ophthalmol. 1969 Nov;53(11):721-48
pubmed: 4982590
Nat Rev Genet. 2013 Jul;14(7):483-95
pubmed: 23752797
Nat Rev Dis Primers. 2017 Mar 23;3:17013
pubmed: 28332488
Front Immunol. 2020 Feb 13;11:65
pubmed: 32117239
Front Neuroenergetics. 2010 May 21;2:
pubmed: 20725515
Cell Rep. 2020 Jun 23;31(12):107776
pubmed: 32579912
Neurobiol Dis. 2002 Apr;9(3):305-18
pubmed: 11950276
Graefes Arch Clin Exp Ophthalmol. 2019 Sep;257(9):1963-1970
pubmed: 31209566
Nat Neurosci. 2020 Oct;23(10):1183-1193
pubmed: 32778792
Mech Ageing Dev. 2021 Jun;196:111473
pubmed: 33766745
Nature. 2021 Jun;594(7863):309-310
pubmed: 34103732
Nat Rev Neurosci. 2006 Jan;7(1):41-53
pubmed: 16371949
Psychoneuroendocrinology. 2009 Aug;34(7):1065-74
pubmed: 19297102
Cereb Cortex. 2013 Oct;23(10):2322-36
pubmed: 22891037
Vet Ophthalmol. 2021 Mar;24 Suppl 1:16-33
pubmed: 33411993
Mol Neurodegener. 2021 Apr 29;16(1):29
pubmed: 33926499
Immunity. 2021 Feb 9;54(2):211-224
pubmed: 33567261
Sci Rep. 2020 Oct 15;10(1):17359
pubmed: 33060618
Nat Commun. 2018 Aug 10;9(1):3209
pubmed: 30097565
Neuron. 2017 Sep 27;96(1):17-42
pubmed: 28957666
Brain. 2013 Sep;136(Pt 9):2697-706
pubmed: 23842566
Neuron. 2011 Sep 8;71(5):799-811
pubmed: 21903074
Front Immunol. 2018 Apr 09;9:586
pubmed: 29686666
Neurobiol Dis. 2020 Aug;142:104953
pubmed: 32445791
Nat Med. 2019 Nov;25(11):1680-1683
pubmed: 31686034
Sci Transl Med. 2020 Feb 5;12(529):
pubmed: 32024799
J Alzheimers Dis. 2018;61(2):553-560
pubmed: 29172001
Exp Eye Res. 2011 Aug;93(2):187-90
pubmed: 20801114
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10515-20
pubmed: 26240337
Front Immunol. 2018 Jun 06;9:1287
pubmed: 29951055
EJNMMI Res. 2020 Jun 15;10(1):65
pubmed: 32542468
J Neurosci. 2000 Jun 15;20(12):4615-26
pubmed: 10844031
J Neurosci Methods. 2020 Apr 1;335:108623
pubmed: 32027890
Prog Brain Res. 2008;173:353-73
pubmed: 18929121
Ann Transl Med. 2015 Jun;3(10):136
pubmed: 26207229
Front Pharmacol. 2021 Mar 10;12:643254
pubmed: 33776778
Invest Ophthalmol Vis Sci. 2013 Sep 05;54(9):5953-8
pubmed: 23920375
Nat Neurosci. 2020 Mar;23(3):311-322
pubmed: 32112059
Neurosci Lett. 2010 Aug 9;480(1):69-72
pubmed: 20609426
Invest Ophthalmol Vis Sci. 2020 Jul 1;61(8):3
pubmed: 32614373
Clin Exp Pharmacol Physiol. 2017 Dec;44 Suppl 1:9-14
pubmed: 28378496
FASEB J. 2017 Apr;31(4):1508-1515
pubmed: 28031319
J Physiol. 1890 Jan;11(1-2):85-158.17
pubmed: 16991945
J Alzheimers Dis Rep. 2021 May 03;5(1):375-387
pubmed: 34189409
Science. 1991 Nov 22;254(5035):1178-81
pubmed: 1957169
Cell Rep. 2018 Jan 2;22(1):269-285
pubmed: 29298427
Neuron. 2016 Jan 6;89(1):37-53
pubmed: 26687838
JAMA Ophthalmol. 2021 Sep 1;139(9):1023-1028
pubmed: 34264281
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Nov;24(11):1044-8
pubmed: 14687510
N Engl J Med. 2013 Jan 10;368(2):107-16
pubmed: 23150908
Ophthalmology. 1996 Jul;103(7):1014-24
pubmed: 8684789
Cold Spring Harb Perspect Med. 2014 Jul 03;4(8):
pubmed: 24993677
Prog Retin Eye Res. 2022 Jan;86:100976
pubmed: 34102318
Nature. 2021 Feb;590(7846):473-479
pubmed: 33408417
Prog Retin Eye Res. 2021 Mar;81:100880
pubmed: 32721458
Pharmaceutics. 2021 Jun 11;13(6):
pubmed: 34208272
Neuron. 2020 Aug 5;107(3):436-453.e12
pubmed: 32485136
Biology (Basel). 2019 May 11;8(2):
pubmed: 31083549
Surv Ophthalmol. 1999 Jun;43 Suppl 1:S27-42
pubmed: 10416745
Neuroimage Clin. 2021;32:102718
pubmed: 34455187
Ann Clin Transl Neurol. 2020 Sep;7(9):1661-1673
pubmed: 32779869
Front Neurosci. 2021 Feb 09;15:639140
pubmed: 33633540
Am J Hum Genet. 2001 Apr;68(4):895-900
pubmed: 11254447
J Alzheimers Dis Rep. 2020 Jun 16;4(1):175-183
pubmed: 32715278
Br J Ophthalmol. 1970 Jul;54(7):461-72
pubmed: 4988400
Nat Med. 2020 Jun;26(6):952-963
pubmed: 32514169
Cell Rep. 2020 Nov 3;33(5):108271
pubmed: 33147455
Science. 2017 Feb 17;355(6326):756-760
pubmed: 28209901
PLoS Biol. 2010 Jan 26;8(1):e1000298
pubmed: 20126261
Neurosci Lett. 1996 Jul 5;212(1):13-6
pubmed: 8823751
Ann Neurol. 2018 Jul;84(1):10-22
pubmed: 29944741
Arch Med Res. 2017 May;48(4):370-377
pubmed: 28889998
Aging Cell. 2017 Jun;16(3):585-593
pubmed: 28371013
Brain Res. 2019 May 1;1710:43-60
pubmed: 30580011
Nat Neurosci. 2016 Aug;19(8):1073-84
pubmed: 27399843
J Neurol. 2011 May;258(5):882-8
pubmed: 21197541
Prog Retin Eye Res. 2021 Jan;80:100875
pubmed: 32659431
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1896-E1905
pubmed: 29437957
Neurology. 1988 Aug;38(8):1285-91
pubmed: 3399080
PLoS One. 2013 Jun 27;8(6):e67094
pubmed: 23826199
Brain. 2016 Apr;139(Pt 4):1226-36
pubmed: 26936941
Mitochondrion. 2017 Sep;36:186-192
pubmed: 28866056
Nature. 1998 Apr 9;392(6676):605-8
pubmed: 9560156
Stroke. 2008 Jan;39(1):24-9
pubmed: 18048851
Front Aging Neurosci. 2018 Jul 05;10:203
pubmed: 30026694
Surv Ophthalmol. 2018 Jan - Feb;63(1):56-74
pubmed: 28666629
Trends Pharmacol Sci. 2020 Dec;41(12):1023-1037
pubmed: 33127098
Cells. 2018 Jun 15;7(6):
pubmed: 29914056
Neuron. 2015 Mar 18;85(6):1244-56
pubmed: 25754821
Ophthalmology. 2014 Nov;121(11):2081-90
pubmed: 24974815
N Engl J Med. 2013 Jan 10;368(2):117-27
pubmed: 23150934
Neurosci Lett. 2018 Jan 18;664:79-83
pubmed: 29133174
Mol Neurodegener. 2021 Jan 13;16(1):2
pubmed: 33441154
Neurology. 2016 Dec 6;87(23):2443-2450
pubmed: 27815399
Invest Ophthalmol Vis Sci. 2010 Jan;51(1):207-16
pubmed: 19850836
Nat Commun. 2014 Jun 10;5:4047
pubmed: 24915161
Med Clin North Am. 2019 Mar;103(2):263-293
pubmed: 30704681
Geroscience. 2020 Dec;42(6):1499-1525
pubmed: 33011937
Trends Biochem Sci. 2021 Apr;46(4):329-343
pubmed: 33323315
Annu Rev Vis Sci. 2020 Sep 15;6:91-114
pubmed: 32936736
Prog Retin Eye Res. 2021 Sep;84:100953
pubmed: 33640464
BMJ. 2021 Jul 5;374:n1682
pubmed: 34226181
Nat Rev Neurol. 2021 Mar;17(3):157-172
pubmed: 33318676
J Vis Exp. 2018 Mar 9;(133):
pubmed: 29578519
Mech Ageing Dev. 2021 Apr;195:111438
pubmed: 33516818
Nature. 2020 Dec;588(7838):459-465
pubmed: 32866962
APL Bioeng. 2021 Mar 16;5(1):011509
pubmed: 33758788
Nat Rev Neurol. 2019 Oct;15(10):565-581
pubmed: 31501588
J Psychiatr Res. 2020 Oct;129:281-288
pubmed: 32882505
Nat Med. 2018 Jul;24(7):931-938
pubmed: 29892066
Graefes Arch Clin Exp Ophthalmol. 2012 Apr;250(4):589-94
pubmed: 22008947
Neurology. 1992 Mar;42(3 Pt 1):631-9
pubmed: 1549228
Cell. 2005 Feb 25;120(4):483-95
pubmed: 15734681
J Alzheimers Dis. 2015;45(1):45-56
pubmed: 25428254
Neurobiol Dis. 2014 Nov;71:44-52
pubmed: 25132557
Ann Neurol. 2006 Jan;59(1):182-5
pubmed: 16278853
Lancet. 2011 Mar 12;377(9769):942-55
pubmed: 21296405
Nat Protoc. 2018 Oct;13(10):2176-2199
pubmed: 30250293
J Neurosci. 2010 Nov 17;30(46):15654-63
pubmed: 21084621
Mol Neurodegener. 2020 Nov 19;15(1):70
pubmed: 33213497
J Neurosci. 2016 Aug 31;36(35):9148-60
pubmed: 27581456
Alzheimers Res Ther. 2020 Apr 27;12(1):49
pubmed: 32340618
Exp Neurol. 2001 Dec;172(2):257-72
pubmed: 11716551
Exp Eye Res. 2009 Apr;88(4):799-807
pubmed: 19217902
Neurol Clin. 2015 Feb;33(1):1-17
pubmed: 25432720
Front Neurosci. 2020 Jun 17;14:577
pubmed: 32625052
Sci Rep. 2020 Jun 17;10(1):9802
pubmed: 32555229
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1738-46
pubmed: 26884166
Arch Ophthalmol. 1979 Feb;97(2):284-5
pubmed: 550797
Ann Neurol. 2020 Mar;87(3):329-338
pubmed: 31953875
Elife. 2022 Feb 22;11:
pubmed: 35191836
J Neurosci. 2015 Oct 07;35(40):13568-76
pubmed: 26446211
J Ophthalmol. 2021 Apr 15;2021:4581909
pubmed: 33953963
PLoS One. 2015 Aug 07;10(8):e0134750
pubmed: 26252902
Front Neuroendocrinol. 2020 Jul;58:100850
pubmed: 32504632
EMBO Mol Med. 2021 Aug 9;13(8):e14781
pubmed: 34338436
Neuron. 2020 Dec 9;108(5):876-886.e4
pubmed: 33108748
Autophagy. 2017 May 4;13(5):982-984
pubmed: 28318364
J Comp Neurol. 2011 Mar 1;519(4):599-620
pubmed: 21246546
J Neurosci. 2008 Sep 17;28(38):9363-76
pubmed: 18799670
Exp Eye Res. 2017 Apr;157:20-27
pubmed: 28242160
Cell. 2020 Dec 10;183(6):1699-1713.e13
pubmed: 33188775
Alzheimers Dement. 2020 Jul;16(7):974-982
pubmed: 32400950
J Cell Biol. 2005 Dec 19;171(6):1001-12
pubmed: 16365166
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Front Nutr. 2021 May 14;8:669846
pubmed: 34055858
Int J Mol Sci. 2021 May 07;22(9):
pubmed: 34066949
Elife. 2017 Oct 10;6:
pubmed: 28994390
Antioxid Redox Signal. 2021 Mar 10;34(8):674-693
pubmed: 32159378
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Prog Retin Eye Res. 2021 Jul;83:100938
pubmed: 33460813
Neurobiol Aging. 2009 Sep;30(9):1350-60
pubmed: 18155324
Cells. 2020 Jul 22;9(8):
pubmed: 32708020
Biomedicines. 2021 May 07;9(5):
pubmed: 34067173
Brain Commun. 2019;1(1):fcz035
pubmed: 31894207
Front Neurol. 2019 Feb 19;10:122
pubmed: 30837941
Nat Commun. 2016 Feb 04;7:10472
pubmed: 26843334
Cells. 2021 Apr 23;10(5):
pubmed: 33922651
Neuron. 2015 May 20;86(4):1000-1014
pubmed: 25937169
Exp Eye Res. 2017 Apr;157:5-12
pubmed: 28223179
Curr Protoc Immunol. 2019 Jun;125(1):e70
pubmed: 30414379
Nat Neurosci. 2011 Sep 27;14(10):1227-35
pubmed: 21952260
Cell. 2015 Jan 15;160(1-2):177-90
pubmed: 25594180
Nat Biotechnol. 2018 Jun;36(5):432-441
pubmed: 29658944
Ann Neurol. 2017 Jul;82(1):128-132
pubmed: 28556232
Science. 2006 Oct 6;314(5796):130-3
pubmed: 17023659
Annu Rev Pathol. 2020 Jan 24;15:235-259
pubmed: 31585519
Neuroimage. 2011 Jan;54 Suppl 1:S204-17
pubmed: 20550967
J Biol Chem. 2008 Oct 31;283(44):29615-9
pubmed: 18650430
J Neurochem. 2018 Mar;144(5):644-650
pubmed: 29222909
Dev Dyn. 2019 Jan;248(1):118-128
pubmed: 30242792
Nat Rev Neurol. 2021 May;17(5):265-266
pubmed: 33727705
Exp Gerontol. 2017 Aug;94:52-58
pubmed: 27845201
Alzheimers Dement. 2015 Jun;11(6):710-7
pubmed: 25510382
Development. 2017 Oct 15;144(20):3698-3705
pubmed: 28870990
Nat Commun. 2020 Feb 3;11(1):667
pubmed: 32015339
Curr Alzheimer Res. 2011 Jun;8(4):330-5
pubmed: 21222594
Dev Cell. 2020 May 18;53(4):473-491.e9
pubmed: 32386599
Alzheimers Res Ther. 2019 Mar 11;11(1):22
pubmed: 30857563
J Glaucoma. 2004 Aug;13(4):340-4
pubmed: 15226664