Phantom Validation of a Conservation of Activity-Based Partial Volume Correction Method for Arterial Input Function in Dynamic PET Imaging.


Journal

Tomography (Ann Arbor, Mich.)
ISSN: 2379-139X
Titre abrégé: Tomography
Pays: Switzerland
ID NLM: 101671170

Informations de publication

Date de publication:
21 03 2022
Historique:
received: 15 01 2022
revised: 10 03 2022
accepted: 16 03 2022
entrez: 22 3 2022
pubmed: 23 3 2022
medline: 25 3 2022
Statut: epublish

Résumé

Dynamic PET (dPET) imaging can be utilized to perform kinetic modelling of various physiologic processes, which are exploited by the constantly expanding range of targeted radiopharmaceuticals. To date, dPET remains primarily in the research realm due to a number of technical challenges, not least of which is addressing partial volume effects (PVE) in the input function. We propose a series of equations for the correction of PVE in the input function and present the results of a validation study, based on a purpose built phantom.

Identifiants

pubmed: 35314646
pii: tomography8020069
doi: 10.3390/tomography8020069
pmc: PMC8938778
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

842-857

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Auteurs

Brandon Driscoll (B)

Quantitative Imaging for Personalized Cancer Medicine (QIPCM)-Techna Institute, University Health Network, Toronto, ON M5G 2C4, Canada.

Tina Shek (T)

Quantitative Imaging for Personalized Cancer Medicine (QIPCM)-Techna Institute, University Health Network, Toronto, ON M5G 2C4, Canada.

Douglass Vines (D)

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Department of Radiation Oncology, University of Toronto, Toronto, ON M5T 1P5, Canada.

Alex Sun (A)

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Department of Radiation Oncology, University of Toronto, Toronto, ON M5T 1P5, Canada.

David Jaffray (D)

Quantitative Imaging for Personalized Cancer Medicine (QIPCM)-Techna Institute, University Health Network, Toronto, ON M5G 2C4, Canada.
Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Department of Radiation Oncology, University of Toronto, Toronto, ON M5T 1P5, Canada.

Ivan Yeung (I)

Quantitative Imaging for Personalized Cancer Medicine (QIPCM)-Techna Institute, University Health Network, Toronto, ON M5G 2C4, Canada.
Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Department of Radiation Oncology, University of Toronto, Toronto, ON M5T 1P5, Canada.

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Classifications MeSH