Low-cost gastrointestinal manometry via silicone-liquid-metal pressure transducers resembling a quipu.
Journal
Nature biomedical engineering
ISSN: 2157-846X
Titre abrégé: Nat Biomed Eng
Pays: England
ID NLM: 101696896
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
25
06
2021
accepted:
19
01
2022
pubmed:
23
3
2022
medline:
22
10
2022
entrez:
22
3
2022
Statut:
ppublish
Résumé
The evaluation of the tone and contractile patterns of the gastrointestinal (GI) tract via manometry is essential for the diagnosis of GI motility disorders. However, manometry is expensive and relies on complex and bulky instrumentation. Here we report the development and performance of an inexpensive and easy-to-manufacture catheter-like device for capturing manometric data across the dynamic range observed in the human GI tract. The device, which we designed to resemble the quipu-knotted strings used by Andean civilizations for the capture and transmission of information-consists of knotted piezoresistive pressure sensors made by infusing a liquid metal (eutectic gallium-indium) through thin silicone tubing. By exploring a range of knotting configurations, we identified optimal design schemes that led to sensing performances comparable to those of commercial devices for GI manometry, as we show for the sensing of GI motility in multiple anatomic sites of the GI tract of anaesthetized pigs. Disposable and customizable piezoresistive catheters may broaden the use of GI manometry in low-resource settings.
Identifiants
pubmed: 35314802
doi: 10.1038/s41551-022-00859-5
pii: 10.1038/s41551-022-00859-5
doi:
Substances chimiques
Silicones
0
Indium
045A6V3VFX
Gallium
CH46OC8YV4
Banques de données
figshare
['10.6084/m9.figshare.14544453', '10.6084/m9.figshare.17434874']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1092-1104Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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