Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis.
Arsenic
Beta cells
Diabetes
Insulin secretion
MicroRNAs
Sequencing
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
17
01
2022
accepted:
17
02
2022
pubmed:
23
3
2022
medline:
18
5
2022
entrez:
22
3
2022
Statut:
ppublish
Résumé
Arsenic is a pervasive environmental toxin that is listed as the top priority for investigation by the Agency for Toxic Substance and Disease Registry. While chronic exposure to arsenic is associated with type 2 diabetes (T2D), the underlying mechanisms are largely unknown. We have recently demonstrated that arsenic treatment of INS-1 832/13 pancreatic beta cells impairs glucose-stimulated insulin secretion (GSIS), a T2D hallmark. We have also shown that arsenic alters the microRNA profile of beta cells. MicroRNAs have a well-established post-transcriptional regulatory role in both normal beta cell function and T2D pathogenesis. We hypothesized that there are microRNA master regulators that shape beta cell gene expression in pathways pertinent to GSIS after exposure to arsenicals. To test this hypothesis, we first treated INS-1 832/13 beta cells with either inorganic arsenic (iAs
Identifiants
pubmed: 35314868
doi: 10.1007/s00204-022-03263-9
pii: 10.1007/s00204-022-03263-9
pmc: PMC9095563
doi:
Substances chimiques
Arsenicals
0
Insulin
0
MicroRNAs
0
Glucose
IY9XDZ35W2
Arsenic
N712M78A8G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1685-1699Subventions
Organisme : NIH HHS
ID : F30 OD031914
Pays : United States
Organisme : NIH HHS
ID : T35 OD010941
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42ES031007
Pays : United States
Informations de copyright
© 2022. The Author(s).
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