Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis.


Journal

Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615

Informations de publication

Date de publication:
06 2022
Historique:
received: 17 01 2022
accepted: 17 02 2022
pubmed: 23 3 2022
medline: 18 5 2022
entrez: 22 3 2022
Statut: ppublish

Résumé

Arsenic is a pervasive environmental toxin that is listed as the top priority for investigation by the Agency for Toxic Substance and Disease Registry. While chronic exposure to arsenic is associated with type 2 diabetes (T2D), the underlying mechanisms are largely unknown. We have recently demonstrated that arsenic treatment of INS-1 832/13 pancreatic beta cells impairs glucose-stimulated insulin secretion (GSIS), a T2D hallmark. We have also shown that arsenic alters the microRNA profile of beta cells. MicroRNAs have a well-established post-transcriptional regulatory role in both normal beta cell function and T2D pathogenesis. We hypothesized that there are microRNA master regulators that shape beta cell gene expression in pathways pertinent to GSIS after exposure to arsenicals. To test this hypothesis, we first treated INS-1 832/13 beta cells with either inorganic arsenic (iAs

Identifiants

pubmed: 35314868
doi: 10.1007/s00204-022-03263-9
pii: 10.1007/s00204-022-03263-9
pmc: PMC9095563
doi:

Substances chimiques

Arsenicals 0
Insulin 0
MicroRNAs 0
Glucose IY9XDZ35W2
Arsenic N712M78A8G

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1685-1699

Subventions

Organisme : NIH HHS
ID : F30 OD031914
Pays : United States
Organisme : NIH HHS
ID : T35 OD010941
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42ES031007
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Jenna E Todero (JE)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Kieran Koch-Laskowski (K)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Qing Shi (Q)

Department of Nutrition, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Matt Kanke (M)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Yu-Han Hung (YH)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Rowan Beck (R)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Department of Nutrition, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Miroslav Styblo (M)

Department of Nutrition, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Praveen Sethupathy (P)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. pr46@cornell.edu.

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