Difficult maintenance of serum drug concentration in methicillin-resistant Staphylococcus aureus toxic shock syndrome during early puerperium.
cesarean section
infection
methicillin-resistant staphylococcus aureus
puerperium
toxic shock syndrome
Journal
The journal of obstetrics and gynaecology research
ISSN: 1447-0756
Titre abrégé: J Obstet Gynaecol Res
Pays: Australia
ID NLM: 9612761
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
revised:
18
02
2022
received:
08
09
2021
accepted:
26
02
2022
pubmed:
23
3
2022
medline:
7
6
2022
entrez:
22
3
2022
Statut:
ppublish
Résumé
Toxic shock syndrome can be caused by methicillin-resistant Staphylococcus aureus (MRSA). During puerperium this condition is rare, and proper treatment during this period has not been clarified. Two patients developed toxic shock syndrome caused by MRSA soon after cesarean section. Despite the administration of antibiotics, both developed severe conditions and one of them required hysterectomy. The dosage was adjusted in the same way as nonpregnancy, but the actual drug concentration was significantly different from expectation. When there is severe infection during the early postpartum period, maintaining drug concentration at optimal levels may be difficult, and this could be life-threatening. Better understanding of the pharmacokinetics and establishment of a method to determine the optimal drug dose during puerperium is required.
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1484-1488Informations de copyright
© 2022 Japan Society of Obstetrics and Gynecology.
Références
Cunningham FG, Leveno KJ, Bloom SL, et al. Williams obstetrics. 25th ed. New York: McGraw-Hill education; 2018.
Deguchi Y, Horiuchi Y, Shojima K, et al. Postpartum methicillin-resistant Staphylococcus aureus toxic shock syndrome caused by a perineal infection. Case Rep Obstet Gynecol. 2018;30(2018):2670179.
Andrews J. Nonmenstrual toxic shock syndrome due to methicillin-resistant Staphylococcus aureus. Obstet Gynecol. 2008;112(4):933-8.
Collet C, Petsaris O, Lafforgue N, et al. Postpartum toxic shock syndrome due to methicillin-resistant Staphylococcus aureus epidemic in community. Eur J Obstet Gynecol Reprod Biol. 2009;144(2):184-5.
Schlievert PM, Kelly JA. Clindamycin-induced suppression of toxic-shock syndrome-associated exotoxin production. J Infect Dis. 1984;149(3):471.
Centers for Disease Control and Prevention. Toxic shock syndrome (other than Streptococcal) (TSS) 2011 case definition. [Cited 28 August 2021.] Available from: https://ndc.services.cdc.gov/case-definitions/toxic-shock-syndrome-2011/
Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2009;66(1):82-98.
Rybak MJ, Le J, Lodise TP, et al. Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: A revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2020;77(11):835-64.