Protein synthesis control in cancer: selectivity and therapeutic targeting.
cancer
protein synthesis
translation and protein quality
translation inhibitors
translational control
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
19 04 2022
19 04 2022
Historique:
revised:
10
12
2021
received:
27
09
2021
accepted:
16
12
2021
pubmed:
23
3
2022
medline:
21
4
2022
entrez:
22
3
2022
Statut:
ppublish
Résumé
Translational control of mRNAs is a point of convergence for many oncogenic signals through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on translational control to appropriately adapt to limited resources while maintaining cell growth and survival, which creates a selective therapeutic window compared to non-transformed cells. In this review, we first discuss how cancer cells modulate the translational machinery to rapidly and selectively synthesize proteins in response to internal oncogenic demands and external factors in the tumor microenvironment. We highlight the clinical potential of compounds that target different translation factors as anti-cancer therapies. Next, we detail how RNA sequence and structural elements interface with the translational machinery and RNA-binding proteins to coordinate the translation of specific pro-survival and pro-growth programs. Finally, we provide an overview of the current and emerging technologies that can be used to illuminate the mechanisms of selective translational control in cancer cells as well as within the microenvironment.
Identifiants
pubmed: 35315941
doi: 10.15252/embj.2021109823
pmc: PMC9016353
doi:
Substances chimiques
RNA, Messenger
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e109823Informations de copyright
© 2022 The Authors.
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