Lymphocytes Are Not Required for Neurogenic Heterotopic Ossification Development after Spinal Cord Injury.
B lymphocytes
T lymphocytes
bone
neurogenic heterotopic ossification
spinal cord injury
Journal
Neurotrauma reports
ISSN: 2689-288X
Titre abrégé: Neurotrauma Rep
Pays: United States
ID NLM: 101773091
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
23
3
2022
pubmed:
24
3
2022
medline:
24
3
2022
Statut:
epublish
Résumé
Neurogenic heterotopic ossifications (NHOs) are incapacitating complications of traumatic brain and spinal cord injuries (SCI) that manifest as abnormal bone formation in periarticular muscles. Using a unique model of NHO after SCI in genetically unmodified mice, we have previously established that the innate immune system plays a key driving role in NHO pathogenesis. The role of adaptive immune cells in NHO pathogenesis, however, remains unexplored in this model. Here we established that B lymphocytes were reduced in the spleen and blood after SCI and increased in muscles of mice in which NHO develops, whereas minimal changes in T cell frequencies were noted. Interestingly,
Identifiants
pubmed: 35317305
doi: 10.1089/neur.2021.0072
pii: 10.1089/neur.2021.0072
pmc: PMC8935476
doi:
Types de publication
Journal Article
Langues
eng
Pagination
87-96Informations de copyright
© Kylie A. Alexander et al., 2022; Published by Mary Ann Liebert, Inc.
Déclaration de conflit d'intérêts
No competing financial interests exist.
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