Characterization of the vasodilator effect of eugenol in isolated human umbilical cord arteries.

Animals Arteries Eugenol / pharmacology Humans Tetraethylammonium / pharmacology Umbilical Cord Vasodilation Vasodilator Agents / pharmacology
Eugenol Human umbilical artery Vasorelaxant

Journal

Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276

Informations de publication

Date de publication:
25 May 2022
Historique:
received: 13 12 2021
revised: 01 03 2022
accepted: 09 03 2022
pubmed: 24 3 2022
medline: 20 4 2022
entrez: 23 3 2022
Statut: ppublish

Résumé

Eugenol (EUG) is a phenylpropanoid widely used in the food and cosmetic industries. It is commonly referred to in the literature by its biological activities such as antioxidant, anti-inflammatory, antimicrobial, and relaxing in organs of laboratory animals, especially in rodent vessels. However, its vasorelaxant potential in human tissue, has not been investigated. Thus, this study characterizes the vasodilatory effect of EUG in the human umbilical artery (HUA). HUAs were isolated, cleaned, sectioned (3-4 mm) and placed in an organ bath (10 mL Krebs Henseleit, 37 °C; and carbogenic mixture). EUG (100-1400 μM), obtained total relaxation of electromechanical contractions induced by KCl (60 mM), and pharmacomechanical contractions (30-1200 μM), induced by serotonin (10 μM) and by histamine (10 μM), showing statistically significant concentrations: 600 μM, 400 μM and 200 μM, and EC

Identifiants

DOI: 10.1016/j.cbi.2022.109890 PMID: 35318036
pubmed: 35318036
pii: S0009-2797(22)00095-3
doi: 10.1016/j.cbi.2022.109890
pii:
doi:

Substances chimiques

Vasodilator Agents 0
Eugenol 3T8H1794QW
Tetraethylammonium 66-40-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109890

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Debora de Menezes Dantas (DM)

Biological Chemistry Department, Postgraduate Program in Biological Chemistry, Regional University of Cariri, Pimenta Campus, 63105-010, Crato, CE, Brazil; Biological Sciences Department, Physiopharmacology of Excitable Cells Laboratory, Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.

Andressa de Alencar Silva (AA)

Biological Sciences Department, Physiopharmacology of Excitable Cells Laboratory, Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.

Luís Pereira-de-Morais (L)

Biological Sciences Department, Physiopharmacology of Excitable Cells Laboratory, Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil. Electronic address: luispereira256@gmail.com.

Carla Mikevely de Sena Bastos (CMS)

Biological Chemistry Department, Postgraduate Program in Biological Chemistry, Regional University of Cariri, Pimenta Campus, 63105-010, Crato, CE, Brazil; Biological Sciences Department, Physiopharmacology of Excitable Cells Laboratory, Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.

Gabriela Lucena Calixto (GL)

Biological Sciences Department, Physiopharmacology of Excitable Cells Laboratory, Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.

Marta Regina Kerntopf (MR)

Biological Chemistry Department, Postgraduate Program in Biological Chemistry, Regional University of Cariri, Pimenta Campus, 63105-010, Crato, CE, Brazil.

Irwin Rose Alencar de Menezes (IRA)

Biological Chemistry Department, Postgraduate Program in Biological Chemistry, Regional University of Cariri, Pimenta Campus, 63105-010, Crato, CE, Brazil.

Daniel Weinreich (D)

University of Maryland, Baltimore, MD, 21201, USA.

Roseli Barbosa (R)

Biological Chemistry Department, Postgraduate Program in Biological Chemistry, Regional University of Cariri, Pimenta Campus, 63105-010, Crato, CE, Brazil; Biological Sciences Department, Physiopharmacology of Excitable Cells Laboratory, Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Characterization of the vasodilator effect of...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Characterization of the vasodilator effect of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Dérivés de l'allylbenzène › Eugénol › Characterization of the vasodilator effect of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterization of the vasodilator effect of...
questionsmedicales.fr › Composés chimiques organiques › Composés onium › Composés d'ammonium quaternaire › Composés de tétraéthyl-ammonium › Tétraéthyl-ammonium › Characterization of the vasodilator effect of...
questionsmedicales.fr › Structures de l'embryon › Foetus › Cordon ombilical › Characterization of the vasodilator effect of...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Characterization of the vasodilator effect of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Vasodilatateurs › Characterization of the vasodilator effect of...