Primary, secondary and compensated male biochemical hypogonadism in people living with HIV (PLWH): relevance of sex hormone-binding globulin (SHBG) measurement and comparison between liquid chromatography-tandem mass spectrometry (LC-MS/MS) and chemiluminescent immunoassay for sex steroids assay.
HIV
SHBG
hypogonadism
sex steroids
testosterone
Journal
The aging male : the official journal of the International Society for the Study of the Aging Male
ISSN: 1473-0790
Titre abrégé: Aging Male
Pays: England
ID NLM: 9808210
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
entrez:
23
3
2022
pubmed:
24
3
2022
medline:
25
3
2022
Statut:
ppublish
Résumé
Data about classification of hypogonadism and estrogen deficiency in male people living with HIV (PLWH) are scanty. To investigate the prevalence and characterization of biochemical hypogonadism and relative estrogen deficiency in male PLWH aged < 50 comparing liquid chromatography-tandem mass spectrometry (LC-MS/MS) with chemiluminescent immunoassay (CI), and combining gonadotropin, sex hormone-binding globulin (SHBG) and serum estradiol (E2) measurements. Prospective, cross-sectional, observational study. Serum total testosterone (TT), E2, gonadotropins, SHBG were measured by CI. TT and E2 were also assessed by LC-MS/MS. Free testosterone (cFT) was calculated by Vermeulen equation. A total of 316 PLWH (45.3 ± 5.3 years) were enrolled. TT and cFT by LC-MS/MS were lower compared to CI ( The prevalence of male hypogonadism results underestimated by CI compared to LC-MS/MS in PLWH, both for TT and cFT. SHBG and gonadotropins are essential for detecting T deficiency.
Sections du résumé
BACKGROUND
UNASSIGNED
Data about classification of hypogonadism and estrogen deficiency in male people living with HIV (PLWH) are scanty.
AIM
UNASSIGNED
To investigate the prevalence and characterization of biochemical hypogonadism and relative estrogen deficiency in male PLWH aged < 50 comparing liquid chromatography-tandem mass spectrometry (LC-MS/MS) with chemiluminescent immunoassay (CI), and combining gonadotropin, sex hormone-binding globulin (SHBG) and serum estradiol (E2) measurements.
METHODS
UNASSIGNED
Prospective, cross-sectional, observational study. Serum total testosterone (TT), E2, gonadotropins, SHBG were measured by CI. TT and E2 were also assessed by LC-MS/MS. Free testosterone (cFT) was calculated by Vermeulen equation.
RESULTS
UNASSIGNED
A total of 316 PLWH (45.3 ± 5.3 years) were enrolled. TT and cFT by LC-MS/MS were lower compared to CI (
CONCLUSIONS
UNASSIGNED
The prevalence of male hypogonadism results underestimated by CI compared to LC-MS/MS in PLWH, both for TT and cFT. SHBG and gonadotropins are essential for detecting T deficiency.
Identifiants
pubmed: 35318882
doi: 10.1080/13685538.2022.2039116
doi:
Substances chimiques
Sex Hormone-Binding Globulin
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM