Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics.
atherosclerosis
cardiovascular disease
chronic obstructive pulmonary disease
cigarette smoke
lung inflammation
oxidative stress
Journal
Clinical science (London, England : 1979)
ISSN: 1470-8736
Titre abrégé: Clin Sci (Lond)
Pays: England
ID NLM: 7905731
Informations de publication
Date de publication:
31 03 2022
31 03 2022
Historique:
received:
17
11
2021
revised:
17
02
2022
accepted:
07
03
2022
entrez:
23
3
2022
pubmed:
24
3
2022
medline:
8
4
2022
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) and atherosclerosis are chronic irreversible diseases, that share a number of common causative factors including cigarette smoking. Atherosclerosis drastically impairs blood flow and oxygen availability to tissues, leading to life-threatening outcomes including myocardial infarction (MI) and stroke. Patients with COPD are most likely to die as a result of a cardiovascular event, with 30% of all COPD-related deaths being attributed to cardiovascular disease (CVD). Both atherosclerosis and COPD involve significant local (i.e. lung, vasculature) and systemic inflammation and oxidative stress, of which current pharmacological treatments have limited efficacy, hence the urgency for the development of novel life-saving therapeutics. Currently these diseases must be treated individually, with no therapies available that can effectively reduce the likelihood of comorbid CVD other than cessation of cigarette smoking. In this review, the important mechanisms that drive atherosclerosis and CVD in people with COPD are explained and we propose that modulation of both the oxidative stress and the inflammatory burden will provide a novel therapeutic strategy to treat both the pulmonary and systemic manifestations related to these diseases.
Identifiants
pubmed: 35319068
pii: 231070
doi: 10.1042/CS20210835
pmc: PMC8968302
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
405-423Informations de copyright
© 2022 The Author(s).
Références
Endocrinology. 2013 Mar;154(3):1069-79
pubmed: 23372021
Br J Pharmacol. 2021 Apr;178(8):1805-1818
pubmed: 33523477
Eur Respir J. 2005 Dec;26(6):1009-15
pubmed: 16319329
Am J Respir Crit Care Med. 2013 Jan 1;187(1):58-64
pubmed: 23144329
Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2594-9
pubmed: 16195477
Atherosclerosis. 2019 Oct;289:109-117
pubmed: 31491742
Int J Endocrinol. 2013;2013:402053
pubmed: 24307898
Respir Res. 2008 Jul 15;9:53
pubmed: 18627612
Am J Respir Crit Care Med. 2021 Mar 1;203(5):553-564
pubmed: 33252985
Trends Immunol. 2004 Jan;25(1):4-7
pubmed: 14698276
Am J Respir Crit Care Med. 2013 Apr 1;187(7):715-20
pubmed: 23328521
Vasc Health Risk Manag. 2005;1(3):199-208
pubmed: 17319105
Chest. 2011 Jan;139(1):165-73
pubmed: 21208876
Respir Med. 2006 Aug;100(8):1307-17
pubmed: 16412623
Vasc Health Risk Manag. 2013;9:105-16
pubmed: 23576873
J Clin Invest. 1994 Dec;94(6):2493-503
pubmed: 7989608
Am J Cardiol. 2009 Feb 2;103(3 Suppl):4A-10A
pubmed: 19166707
Circ Res. 2017 Feb 3;120(3):502-513
pubmed: 28154100
ERJ Open Res. 2021 Nov 01;7(4):
pubmed: 34729369
Curr Atheroscler Rep. 2018 Sep 17;20(11):54
pubmed: 30225613
Lancet Respir Med. 2017 Dec;5(12):935-945
pubmed: 29150410
Heart Vessels. 2015 Nov;30(6):734-9
pubmed: 25086816
Trends Mol Med. 2017 Sep;23(9):850-868
pubmed: 28811171
Int J Chron Obstruct Pulmon Dis. 2020 May 20;15:1135-1142
pubmed: 32547001
J Cardiovasc Pharmacol Ther. 2014 Jan;19(1):5-13
pubmed: 24243991
Heart Vessels. 2003 Sep;18(4):188-92
pubmed: 14520486
Expert Rev Cardiovasc Ther. 2007 Mar;5(2):265-82
pubmed: 17338671
Curr Vasc Pharmacol. 2010 Jul;8(4):573-86
pubmed: 19485925
J Am Coll Cardiol. 2009 Mar 31;53(13):1119-26
pubmed: 19324256
Am J Physiol Heart Circ Physiol. 2013 Nov 15;305(10):H1462-70
pubmed: 24014677
Cardiovasc Res. 2010 Feb 1;85(3):614-21
pubmed: 19797427
J Clin Pharmacol. 1990 Feb;30(2):151-4
pubmed: 2312766
Eur Respir J. 2006 May;27(5):972-9
pubmed: 16446313
J Atheroscler Thromb. 2018 Jun 1;25(6):490-504
pubmed: 29225324
Pharmacoepidemiol Drug Saf. 2018 Apr;27(4):365-372
pubmed: 29405501
Curr Pharm Des. 2010;16(23):2518-25
pubmed: 20550499
Blood. 2012 Apr 5;119(14):3219-25
pubmed: 22318201
Biochem Pharmacol. 2008 Mar 15;75(6):1251-61
pubmed: 18035332
Int J Clin Exp Pathol. 2015 Apr 01;8(4):3451-9
pubmed: 26097529
J Allergy Clin Immunol. 2018 Jun;141(6):2037-2047.e10
pubmed: 29709670
Lipids Health Dis. 2011 Mar 09;10:44
pubmed: 21388551
Thorax. 2008 Apr;63(4):301-5
pubmed: 17951276
Eur Respir J. 2019 Jan 24;53(1):
pubmed: 30545968
Cochrane Database Syst Rev. 2013 Jan 31;(1):CD004816
pubmed: 23440795
Heart Vessels. 2009 May;24(3):164-8
pubmed: 19466515
Int J Chron Obstruct Pulmon Dis. 2017 Jan 21;12:395-402
pubmed: 28176939
Br J Pharmacol. 2019 Oct;176(19):3741-3753
pubmed: 31254285
Blood Cells Mol Dis. 2018 Jul;71:55-62
pubmed: 29550053
J Allergy Clin Immunol. 2016 Jul;138(1):16-27
pubmed: 27373322
Acta Physiol (Oxf). 2017 Apr;219(4):728-756
pubmed: 27381367
Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L425-33
pubmed: 20511341
J Atheroscler Thromb. 2006 Dec;13(6):308-13
pubmed: 17192695
Eur Respir J. 2000 Sep;16(3):534-54
pubmed: 11028671
Am J Physiol Renal Physiol. 2005 May;288(5):F871-80
pubmed: 15821252
J Clin Invest. 2012 Jan;122(1):70-9
pubmed: 22201681
Biochem J. 1993 Jun 1;292 ( Pt 2):509-17
pubmed: 8503884
Arthritis Rheum. 2009 Nov 15;61(11):1580-5
pubmed: 19877084
Ther Adv Chronic Dis. 2016 Jan;7(1):34-51
pubmed: 26770668
Am J Respir Crit Care Med. 2016 Jul 1;194(1):38-47
pubmed: 26771278
Sci Rep. 2016 Feb 15;6:20983
pubmed: 26877172
Am J Hypertens. 2009 Jun;22(6):586-92
pubmed: 19300425
Eur Respir J. 2008 Jan;31(1):204-12
pubmed: 18166598
Circulation. 2002 Jul 9;106(2):246-53
pubmed: 12105166
Eur Respir J. 2004 Dec;24(6):910-7
pubmed: 15572531
Thorax. 2015 Jan;70(1):33-40
pubmed: 25349333
PLoS Med. 2010 Mar 16;7(3):e1000220
pubmed: 20305715
Chron Respir Dis. 2017 May;14(2):117-126
pubmed: 27956645
Int J Chron Obstruct Pulmon Dis. 2018 Jan 17;13:335-349
pubmed: 29403271
J Hypertens. 2017 Jan;35(1):89-97
pubmed: 27759579
Atherosclerosis. 2011 Jan;214(1):3-10
pubmed: 20646709
Am J Respir Crit Care Med. 2008 Oct 1;178(7):695-700
pubmed: 18565952
Physiol Res. 2007;56(1):51-56
pubmed: 16497100
Nat Rev Cardiol. 2020 Jul;17(7):387-401
pubmed: 32203286
Cochrane Database Syst Rev. 2005 Oct 19;(4):CD003566
pubmed: 16235327
Chest. 2001 Aug;120(2):496-501
pubmed: 11502649
Prev Med. 2012 May;54 Suppl:S20-8
pubmed: 22178470
Lancet. 2012 Aug 11;380(9841):581-90
pubmed: 22607822
JAMA Intern Med. 2018 Dec 1;178(12):1681-1690
pubmed: 30422153
Pharmacol Ther. 2015 Nov;155:60-79
pubmed: 26297673
Ther Adv Respir Dis. 2018 Jan-Dec;12:1753465817750524
pubmed: 29355081
Chest. 2007 Jan;131(1):53-9
pubmed: 17218556
N Engl J Med. 2007 Dec 13;357(24):2482-94
pubmed: 18077812
Nature. 2004 Mar 11;428(6979):185-9
pubmed: 15014501
QJM. 1999 May;92(5):239-44
pubmed: 10615478
Int J Chron Obstruct Pulmon Dis. 2016 Aug 26;11:2029-34
pubmed: 27616885
Am J Cardiol. 2007 Mar 15;99(6):808-12
pubmed: 17350371
Arterioscler Thromb Vasc Biol. 2000 May;20(5):1262-75
pubmed: 10807742
Talanta. 2016 May 15;152:54-75
pubmed: 26992495
Circulation. 2006 Apr 4;113(13):1708-14
pubmed: 16585403
Proc (Bayl Univ Med Cent). 2003 Jan;16(1):123-6
pubmed: 16278727
Thorax. 2007 May;62(5):411-5
pubmed: 17311843
Science. 2017 Feb 24;355(6327):842-847
pubmed: 28104796
Chest. 2002 May;121(5 Suppl):156S-159S
pubmed: 12010845
PLoS One. 2012;7(5):e37483
pubmed: 22624038
J Am Coll Cardiol. 2006 Jun 20;47(12):2554-60
pubmed: 16781387
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 33108351
Cardiovasc Res. 2012 Nov 1;96(2):234-43
pubmed: 22752349
Drugs Aging. 2014 Nov;31(11):787-96
pubmed: 25212953
Am J Respir Cell Mol Biol. 2020 Feb;62(2):217-230
pubmed: 31461300
Arterioscler Thromb Vasc Biol. 2019 May;39(5):836-838
pubmed: 31017823
Eur Respir J. 2019 Jan 24;53(1):
pubmed: 30545972
Hypertension. 2018 Mar;71(3):499-506
pubmed: 29358458
Clin Sci (Lond). 2014 Feb;126(4):253-65
pubmed: 24144354
Hypertension. 2006 Aug;48(2):278-85
pubmed: 16801489
Am J Respir Crit Care Med. 2010 Jul 1;182(1):34-40
pubmed: 20203243
Br J Pharmacol. 2019 Jun;176(12):1818-1828
pubmed: 29952002
Am J Nephrol. 2006;26(6):531-5
pubmed: 17159340
Circ Res. 2007 Mar 30;100(6):923-9
pubmed: 17332430
COPD. 2018 Oct;15(5):496-502
pubmed: 30475645
Arch Bronconeumol. 2017 Mar;53(3):128-149
pubmed: 28274597
Antioxidants (Basel). 2018 Oct 19;7(10):
pubmed: 30347720
Clin Sci (Lond). 2016 Jul 1;130(13):1039-50
pubmed: 27215677
Eur Respir J. 2005 Jul;26(1):52-9
pubmed: 15994389
Curr Vasc Pharmacol. 2014 May;12(3):403-11
pubmed: 24846230
Eur J Intern Med. 2008 Mar;19(2):104-8
pubmed: 18249305
Am J Respir Crit Care Med. 2018 Mar 15;197(6):834-835
pubmed: 29106290
Circ Res. 1990 Jan;66(1):185-90
pubmed: 2153060
Balkan Med J. 2017 May 5;34(3):226-231
pubmed: 28443567
Chest. 2013 Mar;143(3):798-807
pubmed: 23460157
Ter Arkh. 2019 Mar 29;91(3):22-26
pubmed: 31094454
J Biol Chem. 2002 Jul 5;277(27):24625-30
pubmed: 11983688
Curr Hypertens Rep. 2010 Apr;12(2):135-42
pubmed: 20424957
Thorax. 2005 Apr;60(4):293-300
pubmed: 15790984
Atherosclerosis. 2004 Jun;174(2):349-56
pubmed: 15136066
Eur J Pharmacol. 2019 Jan 5;842:99-110
pubmed: 30336140
Eur Respir J. 2010 Sep;36(3):503-8
pubmed: 20413534
Chest. 2019 Jul;156(1):92-100
pubmed: 30978330
Am J Respir Crit Care Med. 2011 Jan 1;183(1):50-8
pubmed: 20709821
Thorax. 2011 Sep;66(9):769-74
pubmed: 21507906
Adv Exp Med Biol. 2010;661:299-308
pubmed: 20204738
Circ Res. 2003 Nov 28;93(11):1015-7
pubmed: 14645130
Hypertension. 2001 Aug;38(2):274-9
pubmed: 11509489
Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1801-8
pubmed: 11701469
Arterioscler Thromb. 1993 Feb;13(2):197-204
pubmed: 7678986
Respir Med. 2017 Oct;131:118-124
pubmed: 28947018
Pharmaceuticals (Basel). 2010 Mar 08;3(3):514-540
pubmed: 27713266
Thorax. 1999 Jul;54(7):565-7
pubmed: 10377197
Br J Clin Pharmacol. 2009 Jan;67(1):99-109
pubmed: 19006546
N Engl J Med. 2003 Apr 10;348(15):1435-41
pubmed: 12686699
Drug Saf. 1999 Oct;21(4):253-66
pubmed: 10514018
Am J Respir Cell Mol Biol. 2014 Feb;50(2):347-57
pubmed: 24032444
Eur Respir J. 2019 Jul 25;54(1):
pubmed: 31285306
Respirology. 2014 Jan;19(1):74-9
pubmed: 23834671
Thromb J. 2004 Jan 14;2(1):1
pubmed: 14723795
Eur Heart J Acute Cardiovasc Care. 2012 Apr;1(1):60-74
pubmed: 24062891
Prostaglandins Leukot Med. 1987 Sep;29(1):49-59
pubmed: 3478738
Front Immunol. 2014 Nov 10;5:570
pubmed: 25426119
Eur Respir J. 2007 May;29(5):906-13
pubmed: 17301099
J Cardiovasc Pharmacol Ther. 2014 Nov;19(6):501-15
pubmed: 24872348
Nat Clin Pract Rheumatol. 2006 Feb;2(2):99-106
pubmed: 16932663
Immunity. 2017 Oct 17;47(4):621-634
pubmed: 29045897
Circulation. 2004 Jun 1;109(21):2617-25
pubmed: 15173044
Am J Respir Crit Care Med. 2012 May 15;185(10):1065-72
pubmed: 22427534
Open Respir Med J. 2014 Dec 31;8:59-65
pubmed: 25674175
Respir Med. 2018 Aug;141:165-171
pubmed: 30053963
Circulation. 2004 Aug 17;110(7):856-61
pubmed: 15289372
Eur Heart J. 2004 Jul;25(14):1197-207
pubmed: 15246637
J Cell Mol Med. 2001 Oct-Dec;5(4):378-87
pubmed: 12067471
Am J Respir Crit Care Med. 2016 Apr 1;193(7):717-26
pubmed: 26550687
Am J Pathol. 2002 Oct;161(4):1395-407
pubmed: 12368212
Respir Res. 2017 Jun 19;18(1):124
pubmed: 28629419
Eur Respir J. 2006 Jul;28(1):219-42
pubmed: 16816350
Semin Respir Crit Care Med. 2005 Apr;26(2):142-53
pubmed: 16088433
Respir Res. 2019 Jan 23;20(1):17
pubmed: 30674312
Respirology. 2018 Nov;23(11):1023-1031
pubmed: 29696728
Coron Artery Dis. 2004 Aug;15(5):251-8
pubmed: 15238821
Am J Respir Crit Care Med. 2015 Aug 15;192(4):523-5
pubmed: 26051430
J Smooth Muscle Res. 2014;50:18-28
pubmed: 24770446
J Atheroscler Thromb. 2010 Feb 26;17(2):115-30
pubmed: 20145358
Respir Res. 2016 Jul 19;17(1):84
pubmed: 27435477
N Engl J Med. 2014 Dec 25;371(26):2488-98
pubmed: 25426837
Nature. 2005 Sep 15;437(7057):426-31
pubmed: 16163360
Sci Rep. 2020 Nov 4;10(1):18973
pubmed: 33149113
Am Heart J. 2018 Jul;201:124-135
pubmed: 29778671
Eur Heart J. 1987 Dec;8 Suppl M:3-8
pubmed: 2897299
Int J Cardiol. 2015 Jul 15;191:187-93
pubmed: 25965630
Int J Chron Obstruct Pulmon Dis. 2014 Oct 17;9:1207-24
pubmed: 25378921
PLoS One. 2016 May 19;11(5):e0156135
pubmed: 27196051
BMJ. 2004 Nov 27;329(7477):1248-9
pubmed: 15564232
Arterioscler Thromb Vasc Biol. 2019 May;39(5):876-887
pubmed: 30786740
Clin Sci (Lond). 2019 Apr 12;133(7):885-904
pubmed: 30979844
J Am Coll Cardiol. 2009 May 5;53(18):1708-15
pubmed: 19406347
Int J Mol Sci. 2019 Sep 04;20(18):
pubmed: 31487864