The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.

Alzheimer Disease / pathology Amyloid beta-Peptides / metabolism Animals Disease Models, Animal Disease Progression Mice Mice, Transgenic Microglia / metabolism Niacin / pharmacology Plaque, Amyloid / pathology Receptors, G-Protein-Coupled / metabolism

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
23 03 2022
Historique:
entrez: 23 3 2022
pubmed: 24 3 2022
medline: 27 4 2022
Statut: ppublish

Résumé

Increased dietary intake of niacin has been correlated with reduced risk of Alzheimer's disease (AD). Niacin serves as a high-affinity ligand for the receptor HCAR2 (GPR109A). In the brain, HCAR2 is expressed selectively by microglia and is robustly induced by amyloid pathology in AD. The genetic inactivation of

Identifiants

DOI: 10.1126/scitranslmed.abl7634 PMID: 35320002 PMC: PMC10161396
pubmed: 35320002
doi: 10.1126/scitranslmed.abl7634
pmc: PMC10161396
mid: NIHMS1891967
doi:

Substances chimiques

Amyloid beta-Peptides 0
Hcar2 protein, mouse 0
Receptors, G-Protein-Coupled 0
Niacin 2679MF687A

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabl7634

Subventions

Organisme : NCI NIH HHS
ID : P30 CA082709
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005146
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG051495
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG076610
Pays : United States

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Auteurs

Miguel Moutinho (M)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0003-0525-9145

Shweta S Puntambekar (SS)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Andy P Tsai (AP)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0001-6400-544X

Israel Coronel (I)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Peter B Lin (PB)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0002-8954-9045

Brad T Casali (BT)

Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Pablo Martinez (P)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Adrian L Oblak (AL)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0003-1210-8791

Cristian A Lasagna-Reeves (CA)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0002-5499-3082

Bruce T Lamb (BT)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0001-8507-2561

Gary E Landreth (GE)

Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0002-8808-424X

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › Eucaryotes › Animaux › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › Cellules › Névroglie › Microglie › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Acide nicotinique › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque amyloïde › The niacin receptor HCAR2 modulates microglial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › The niacin receptor HCAR2 modulates microglial...