Visual interpretation of brain hypometabolism related to neurological long COVID: a French multicentric experience.
Brainstem
COVID-19
Cerebellum
FDG
Limbic regions
Long COVID
Olfactory bulb
PET
SARS-CoV-2
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
10
12
2021
accepted:
01
03
2022
pubmed:
24
3
2022
medline:
7
7
2022
entrez:
23
3
2022
Statut:
ppublish
Résumé
This multicentre study aimed to provide a qualitative and consensual description of brain hypometabolism observed through the visual analysis of From the beginning of August 2021 to the end of October 2021, the brain On the 143 brain The proposed PET metabolic pattern is easily identified upon visual interpretation in clinical routine for approximately one half of patients with suspected neurological long COVID, requiring special consideration for frontobasal paramedian regions, the brainstem and the cerebellum, and certainly further adapted follow-up and medical care, while the second half of patients have normal brain PET metabolism on average 10.9 months from symptom onset.
Sections du résumé
BACKGROUND
This multicentre study aimed to provide a qualitative and consensual description of brain hypometabolism observed through the visual analysis of
METHODS
From the beginning of August 2021 to the end of October 2021, the brain
RESULTS
On the 143 brain
CONCLUSION
The proposed PET metabolic pattern is easily identified upon visual interpretation in clinical routine for approximately one half of patients with suspected neurological long COVID, requiring special consideration for frontobasal paramedian regions, the brainstem and the cerebellum, and certainly further adapted follow-up and medical care, while the second half of patients have normal brain PET metabolism on average 10.9 months from symptom onset.
Identifiants
pubmed: 35320385
doi: 10.1007/s00259-022-05753-5
pii: 10.1007/s00259-022-05753-5
pmc: PMC8941296
doi:
Substances chimiques
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
3197-3202Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Greenhalgh T, Knight M, A’Court C, Buxton M, Husain L. Management of post-acute covid-19 in primary care. BMJ. 2020;370:m3026.
doi: 10.1136/bmj.m3026
Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, et al. Brain imaging before and after COVID-19 in UK Biobank. Neurology; 2021 Jun. Available from: http://medrxiv.org/lookup/doi/10.1101/2021.06.11.21258690 .
Manca R, De Marco M, Ince PG, Venneri A. Heterogeneity in regional damage detected by neuroimaging and neuropathological studies in older adults with COVID-19: a cognitive-neuroscience systematic review to inform the long-term impact of the virus on neurocognitive trajectories. Front Aging Neurosci. 2021;13:646908.
doi: 10.3389/fnagi.2021.646908
Guedj E, Campion JY, Dudouet P, Kaphan E, Bregeon F, Tissot-Dupont H, et al. 18F-FDG brain PET hypometabolism in patients with long COVID. Eur J Nucl Med Mol Imaging. 2021;48:2823–33.
doi: 10.1007/s00259-021-05215-4
Crook H, Raza S, Nowell J, Young M, Edison P. Long covid—mechanisms, risk factors, and management. BMJ. 2021;n1648.
Dani M, Dirksen A, Taraborrelli P, Torocastro M, Panagopoulos D, Sutton R, et al. Autonomic dysfunction in ‘long COVID’: rationale, physiology and management strategies. Clin Med. 2021;21:e63–7.
doi: 10.7861/clinmed.2020-0896
Guedj E, Varrone A, Boellaard R, Albert NL, Barthel H, van Berckel B, et al. EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3. Eur J Nucl Med Mol Imaging. 2021 [cited 2021 Dec 10]; Available from: https://link.springer.com/10.1007/s00259-021-05603-w .
Morbelli S, Ekmekcioglu O, Barthel H, Albert NL, Boellaard R, Cecchin D, et al. COVID-19 and the brain: impact on nuclear medicine in neurology. Eur J Nucl Med Mol Imaging. 2020;47:2487–92.
doi: 10.1007/s00259-020-04965-x
Kas A, Soret M, Pyatigoskaya N, Habert M-O, Hesters A, Le Guennec L, et al. The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study. Eur J Nucl Med Mol Imaging. 2021;48:2543–57.
doi: 10.1007/s00259-020-05178-y
Blazhenets G, Schroeter N, Bormann T, Thurow J, Wagner D, Frings L, et al. Slow but evident recovery from neocortical dysfunction and cognitive impairment in a series of chronic COVID-19 patients. J Nucl Med. 2021;62:910–5.
doi: 10.2967/jnumed.121.262128
Dressing A, Bormann T, Blazhenets G, Schroeter N, Walter LI, Thurow J, et al. Neuropsychological profiles and cerebral glucose metabolism in neurocognitive Long COVID-syndrome. J Nucl Med. 2021;jnumed.121.262677.
Guedj E, Lazarini F, Morbelli S, Ceccaldi M, Hautefort C, Kas A, et al. Long COVID and the brain network of Proust’s madeleine: targeting the olfactory pathway. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2021;27:1196–8.
Morbelli S, Chiola S, Donegani MI, Arnaldi D, Pardini M, Mancini R, et al. Metabolic correlates of olfactory dysfunction in COVID-19 and Parkinson’s disease (PD) do not overlap. Eur J Nucl Med Mol Imaging. 2022 [cited 2022 Jan 19]; Available from: https://link.springer.com/10.1007/s00259-021-05666-9 .
Guedj E, Tastevin M, Verger A, Richieri R. Brain PET imaging in psychiatric disorders. Ref Module Biomed Sci. Elsevier; 2021 [cited 2021 Dec 10]. p. B9780128229606000000. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780128229606000909 .