Evaluation of the Bactericidal Activity of Galectins.
Antimicrobial
Blood group–positive microbes
Galectin
Innate immune lectin
Molecular mimicry
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
23
3
2022
pubmed:
24
3
2022
medline:
26
3
2022
Statut:
ppublish
Résumé
Over a century ago, Karl Landsteiner discovered that blood group antigens could predict the immunological outcome of red blood cell transfusion. While the discovery of ABO(H) blood group antigens revolutionized transfusion medicine, many questions remain regarding the development and regulation of naturally occurring anti-blood group antibody formation. Early studies suggested that blood group antibodies develop following stimulation by bacteria that express blood group antigens. While this may explain the development of anti-blood group antibodies in blood group-negative individuals, how blood group-positive individuals protect themselves against blood group-positive microbes remained unknown. Recent studies suggest that several members of the galectin family specifically target blood group-positive microbes, thereby providing innate immune protection against blood group antigen-positive microbes regardless of the blood group status of an individual. Importantly, subsequent studies suggest that this unique form of immunity may not be limited to blood group expressing microbes, but may reflect a more generalized form of innate immunity against molecular mimicry. As this form of antimicrobial activity represents a unique and unprecedented form of immunity, we will examine important considerations and methodological approaches that can be used when seeking to ascertain the potential antimicrobial activity of various members of the galectin family.
Identifiants
pubmed: 35320543
doi: 10.1007/978-1-0716-2055-7_27
doi:
Substances chimiques
Blood Group Antigens
0
Galectins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
517-531Subventions
Organisme : NHLBI NIH HHS
ID : F31 HL138934
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL154034
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA242109
Pays : United States
Informations de copyright
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.
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