SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation.
COVID-19
SARS-CoV-2 spike protein 1
complement system
endothelial dysfunction
inflammation
thrombosis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
12
2021
accepted:
08
02
2022
entrez:
24
3
2022
pubmed:
25
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability of SARS-CoV-2 to infect and replicate in endothelial cells, it has been poorly investigated whether, in the complexity of viral infection in the human host, specific viral elements alone can induce endothelial damage. Detection of circulating spike protein in the sera of severe COVID-19 patients was evaluated by ELISA.
Identifiants
pubmed: 35320941
doi: 10.3389/fimmu.2022.827146
pmc: PMC8936079
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Complement System Proteins
9007-36-7
AMP-Activated Protein Kinases
EC 2.7.11.31
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
827146Informations de copyright
Copyright © 2022 Perico, Morigi, Galbusera, Pezzotta, Gastoldi, Imberti, Perna, Ruggenenti, Donadelli, Benigni and Remuzzi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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