DOK2 Has Prognostic and Immunologic Significance in Adults With Acute Myeloid Leukemia: A Novel Immune-Related Therapeutic Target.

DOK2 acute myeloid leukemia immune microenvironment prognostic biomarker therapeutic target

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2022
Historique:
received: 23 12 2021
accepted: 09 02 2022
entrez: 24 3 2022
pubmed: 25 3 2022
medline: 25 3 2022
Statut: epublish

Résumé

The role of downstream tyrosine kinase 2 (DOK2), a major member of the DOK family, remains poorly defined in acute myeloid leukemia (AML). Herein, we investigated the expression levels, clinical outcomes, and biological functions of DOK2 in patients with AML. Datasets were obtained from the Cancer Genome Atlas (TCGA) database for transcriptomic and clinical information. Nomogram construction and assessment were conducted using Cox regression analysis, receiver operating characteristic (ROC) curves, and calibration plots. Public databases, including the Gene Expression Omnibus, Cancer Cell Line Encyclopedia, LinkedOmics, GeneMANIA, TISIDB, and Gene Set Cancer Analysis, were employed for relevant bioinformatic studies. Moreover, we utilized the CIBERSORT algorithm to evaluate the level of infiltration of immune cells into the bone marrow microenvironment. We observed that DOK2 transcription levels were markedly upregulated in AML samples ( We suggest that elevated DOK2 expression could be an unfavorable prognostic indicator of survival in patients with AML. Our findings provide new insights into the role of DOK2 in AML, with promising clinical implications.

Sections du résumé

Background UNASSIGNED
The role of downstream tyrosine kinase 2 (DOK2), a major member of the DOK family, remains poorly defined in acute myeloid leukemia (AML). Herein, we investigated the expression levels, clinical outcomes, and biological functions of DOK2 in patients with AML.
Methods UNASSIGNED
Datasets were obtained from the Cancer Genome Atlas (TCGA) database for transcriptomic and clinical information. Nomogram construction and assessment were conducted using Cox regression analysis, receiver operating characteristic (ROC) curves, and calibration plots. Public databases, including the Gene Expression Omnibus, Cancer Cell Line Encyclopedia, LinkedOmics, GeneMANIA, TISIDB, and Gene Set Cancer Analysis, were employed for relevant bioinformatic studies. Moreover, we utilized the CIBERSORT algorithm to evaluate the level of infiltration of immune cells into the bone marrow microenvironment.
Results UNASSIGNED
We observed that DOK2 transcription levels were markedly upregulated in AML samples (
Conclusion UNASSIGNED
We suggest that elevated DOK2 expression could be an unfavorable prognostic indicator of survival in patients with AML. Our findings provide new insights into the role of DOK2 in AML, with promising clinical implications.

Identifiants

pubmed: 35321466
doi: 10.3389/fmed.2022.842383
pmc: PMC8935080
doi:

Types de publication

Journal Article

Langues

eng

Pagination

842383

Informations de copyright

Copyright © 2022 Xu, Dong, Wang and Chen.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Jiaxuan Xu (J)

Department of Hematology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Xiaoqing Dong (X)

Department of Hematology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Ruoyi Wang (R)

Department of Hematology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Bing Chen (B)

Department of Hematology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Classifications MeSH