Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects.
Gut microbiota
Intestinal microbiome
Metabolomics
Nanomaterial
Oral nanoparticle administration
SiO2 nanoparticles
Silver nanoparticles
Journal
Particle and fibre toxicology
ISSN: 1743-8977
Titre abrégé: Part Fibre Toxicol
Pays: England
ID NLM: 101236354
Informations de publication
Date de publication:
23 03 2022
23 03 2022
Historique:
received:
30
11
2021
accepted:
01
03
2022
entrez:
24
3
2022
pubmed:
25
3
2022
medline:
15
4
2022
Statut:
epublish
Résumé
The oral uptake of nanoparticles is an important route of human exposure and requires solid models for hazard assessment. While the systemic availability is generally low, ingestion may not only affect gastrointestinal tissues but also intestinal microbes. The gut microbiota contributes essentially to human health, whereas gut microbial dysbiosis is known to promote several intestinal and extra-intestinal diseases. Gut microbiota-derived metabolites, which are found in the blood stream, serve as key molecular mediators of host metabolism and immunity. Gut microbiota and the plasma metabolome were analyzed in male Wistar rats receiving either SiO The combined profiling of intestinal microbiome and plasma metabolome may serve as an early and sensitive indicator of gut microbiome changes induced by orally administered nanoparticles; this will help to recognize potential adverse effects of these changes to the host.
Sections du résumé
BACKGROUND
The oral uptake of nanoparticles is an important route of human exposure and requires solid models for hazard assessment. While the systemic availability is generally low, ingestion may not only affect gastrointestinal tissues but also intestinal microbes. The gut microbiota contributes essentially to human health, whereas gut microbial dysbiosis is known to promote several intestinal and extra-intestinal diseases. Gut microbiota-derived metabolites, which are found in the blood stream, serve as key molecular mediators of host metabolism and immunity.
RESULTS
Gut microbiota and the plasma metabolome were analyzed in male Wistar rats receiving either SiO
CONCLUSIONS
The combined profiling of intestinal microbiome and plasma metabolome may serve as an early and sensitive indicator of gut microbiome changes induced by orally administered nanoparticles; this will help to recognize potential adverse effects of these changes to the host.
Identifiants
pubmed: 35321750
doi: 10.1186/s12989-022-00459-w
pii: 10.1186/s12989-022-00459-w
pmc: PMC8941749
doi:
Substances chimiques
Silver
3M4G523W1G
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21Informations de copyright
© 2022. The Author(s).
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