Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals.

Alzheimer Disease / pathology Amyloid beta-Peptides / metabolism Animals Cognitive Dysfunction / diagnostic imaging Locus Coeruleus / metabolism Positron-Emission Tomography tau Proteins / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
23 03 2022
Historique:
received: 15 07 2021
accepted: 23 02 2022
entrez: 24 3 2022
pubmed: 25 3 2022
medline: 13 4 2022
Statut: epublish

Résumé

Animal and human imaging research reported that the presence of cortical Alzheimer's Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with altered neuronal activity and circuitry failure, together facilitating clinical progression. The locus coeruleus (LC), one of the initial subcortical regions harboring pretangle hyperphosphorylated tau, has widespread connections to the cortex modulating cognition. Here we investigate whether LC's in-vivo neuronal activity and functional connectivity (FC) are associated with cognitive decline in conjunction with beta-amyloid. We combined functional MRI of a novel versus repeated face-name paradigm, beta-amyloid-PET and longitudinal cognitive data of 128 cognitively unimpaired older individuals. We show that LC activity and LC-FC with amygdala and hippocampus was higher during novelty. We also demonstrated that lower novelty-related LC activity and LC-FC with hippocampus and parahippocampus were associated with steeper beta-amyloid-related cognitive decline. Our results demonstrate the potential of LC's functional properties as a gauge to identify individuals at-risk for AD-related cognitive decline.

Identifiants

DOI: 10.1038/s41467-022-28986-2 PMID: 35322012 PMC: PMC8943159
pubmed: 35322012
doi: 10.1038/s41467-022-28986-2
pii: 10.1038/s41467-022-28986-2
pmc: PMC8943159
doi:

Substances chimiques

Amyloid beta-Peptides 0
tau Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1571

Subventions

Organisme : NIBIB NIH HHS
ID : P41 EB022544
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR021110
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG036694
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR019307
Pays : United States
Organisme : NIH HHS
ID : S10 OD018035
Pays : United States
Organisme : NIH HHS
ID : S10 OD010364
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG068062
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023043
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB013180
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG046396
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG076153
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015896
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062559
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023401
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s).

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Auteurs

Prokopis C Prokopiou (PC)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-5444-8359

Nina Engels-Domínguez (N)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.
ORCID: 0000-0002-9871-6829

Kathryn V Papp (KV)

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Matthew R Scott (MR)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Biostatistics, Boston University, Boston, MA, USA.

Aaron P Schultz (AP)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
The Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Christoph Schneider (C)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Michelle E Farrell (ME)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Rachel F Buckley (RF)

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Melbourne School of Psychological Sciences, University of Melbourne, Parkville, VIC, Australia.
ORCID: 0000-0002-5356-5537

Yakeel T Quiroz (YT)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-9714-8244

Georges El Fakhri (G)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Dorene M Rentz (DM)

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Reisa A Sperling (RA)

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Keith A Johnson (KA)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Heidi I L Jacobs (HIL)

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. hjacobs@mgh.harvard.edu.
Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands. hjacobs@mgh.harvard.edu.
ORCID: 0000-0001-7620-3822

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Lower novelty-related locus coeruleus function...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Lower novelty-related locus coeruleus function...
questionsmedicales.fr › Eucaryotes › Animaux › Lower novelty-related locus coeruleus function...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Lower novelty-related locus coeruleus function...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Métencéphale › Pont › Tegmentum pontin › Locus ceruleus › Lower novelty-related locus coeruleus function...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Lower novelty-related locus coeruleus function...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Lower novelty-related locus coeruleus function...