Physical Interaction between Cyclin-Dependent Kinase 5 (CDK5) and Clock Factors Affects the Circadian Rhythmicity in Peripheral Oscillators.
CDK5 circadian
mouse embryonic fibroblasts
period length
phosphorylation
Journal
Clocks & sleep
ISSN: 2624-5175
Titre abrégé: Clocks Sleep
Pays: Switzerland
ID NLM: 101736579
Informations de publication
Date de publication:
09 Mar 2022
09 Mar 2022
Historique:
received:
17
12
2021
revised:
22
01
2022
accepted:
01
03
2022
entrez:
24
3
2022
pubmed:
25
3
2022
medline:
25
3
2022
Statut:
epublish
Résumé
Circadian rhythms are self-sustained oscillators with a period of 24 h that is based on the output of transcriptional and post-translational feedback loops. Phosphorylation is considered one of the most important post-translational modifications affecting rhythmicity from cyanobacteria to mammals. For example, the lack of cyclin-dependent kinase 5 (CDK5) shortened the period length of the circadian oscillator in the Suprachiasmatic Nuclei (SCN) of mice via the destabilization of the PERIOD 2 (PER2) protein. Here, we show that CDK5 kinase activity and its interaction with clock components, including PER2 and CLOCK, varied over time in mouse embryonic fibroblast cells. Furthermore, the deletion of
Identifiants
pubmed: 35323171
pii: clockssleep4010017
doi: 10.3390/clockssleep4010017
pmc: PMC8946863
doi:
Types de publication
Journal Article
Langues
eng
Pagination
185-201Références
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