Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia.

CYP7A1 LDL uptake LDLRAP1 LRP6 autosomal dominant hypercholesterolemia linkage analysis next-generation sequencing oligogenic hypercholesterolemia polygenic risk score protein structural models

Journal

Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790

Informations de publication

Date de publication:
18 Mar 2022
Historique:
received: 21 01 2022
revised: 10 03 2022
accepted: 16 03 2022
entrez: 24 3 2022
pubmed: 25 3 2022
medline: 25 3 2022
Statut: epublish

Résumé

Autosomal Dominant Hypercholesterolemia (ADH) is a genetic disorder caused by pathogenic variants in

Identifiants

pubmed: 35323704
pii: metabo12030262
doi: 10.3390/metabo12030262
pmc: PMC8955453
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL107816
Pays : United States

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Auteurs

Youmna Ghaleb (Y)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory of Biochemistry and Molecular Therapeutics (LBTM), Faculty of Pharmacy, Pôle Technologie-Santé (PTS), Saint-Joseph University, Beirut 1004 2020, Lebanon.

Sandy Elbitar (S)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory of Biochemistry and Molecular Therapeutics (LBTM), Faculty of Pharmacy, Pôle Technologie-Santé (PTS), Saint-Joseph University, Beirut 1004 2020, Lebanon.

Anne Philippi (A)

Institut Cochin, Bâtiment Faculté Inserm U1016, Cnrs UMR8104, Université de Paris Faculté de Médecine, F-75014 Paris, France.

Petra El Khoury (P)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory of Biochemistry and Molecular Therapeutics (LBTM), Faculty of Pharmacy, Pôle Technologie-Santé (PTS), Saint-Joseph University, Beirut 1004 2020, Lebanon.

Yara Azar (Y)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory of Biochemistry and Molecular Therapeutics (LBTM), Faculty of Pharmacy, Pôle Technologie-Santé (PTS), Saint-Joseph University, Beirut 1004 2020, Lebanon.
Laboratory for Vascular Translational Science, Paris Cité University, Sorbonne Paris Nord University, F-75013 Paris, France.

Miangaly Andrianirina (M)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.

Alexia Loste (A)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory for Vascular Translational Science, Paris Cité University, Sorbonne Paris Nord University, F-75013 Paris, France.

Yara Abou-Khalil (Y)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory of Biochemistry and Molecular Therapeutics (LBTM), Faculty of Pharmacy, Pôle Technologie-Santé (PTS), Saint-Joseph University, Beirut 1004 2020, Lebanon.
Laboratory for Vascular Translational Science, Paris Cité University, Sorbonne Paris Nord University, F-75013 Paris, France.

Gaël Nicolas (G)

Laboratory for Vascular Translational Science, Paris Cité University, Sorbonne Paris Nord University, F-75013 Paris, France.
INSERM U1149, CNRS ERL 8252, Centre de Recherche sur l'Inflammation, F-75018 Paris, France.

Marie Le Borgne (M)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory for Vascular Translational Science, Paris Cité University, Sorbonne Paris Nord University, F-75013 Paris, France.

Philippe Moulin (P)

Department of Endocrinology, Nutrition and Metabolic Diseases, Hospices Civils de Lyon, Louis Pradel Cardiovascular Hospital, F-69500 Bron, France.
CarMen Laboratory, INSERM U1060, INRAE U1397, Université Lyon 1, F-69921 Oullins, France.

Mathilde Di-Filippo (M)

CarMen Laboratory, INSERM U1060, INRAE U1397, Université Lyon 1, F-69921 Oullins, France.
Hospices Civils de Lyon, Department of Biochemistry and Molecular Biology, F-69500 Bron, France.

Sybil Charrière (S)

Department of Endocrinology, Nutrition and Metabolic Diseases, Hospices Civils de Lyon, Louis Pradel Cardiovascular Hospital, F-69500 Bron, France.
CarMen Laboratory, INSERM U1060, INRAE U1397, Université Lyon 1, F-69921 Oullins, France.

Michel Farnier (M)

EA 7460 Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), Université de Bourgogne-Franche Comté, F-21078 Dijon, France.

Cécile Yelnick (C)

Département de Médecine Interne et Immunologie Clinique Centre de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO) CHU de Lille, F-59037 Lille, France.
U1167 Risk Factors and Molecular Determinants of Aging-Related Diseases, Inserm CHU de Lille, Lille University, F-59000 Lille, France.

Valérie Carreau (V)

Department of Endocrinology and Prevention of Cardiovascular Disease, Institute of Cardio Metabolism and Nutrition (ICAN), La Pitié-Salpêtrière Hospital, AP-HP, F-75005 Paris, France.

Jean Ferrières (J)

Department of Cardiology, Toulouse Rangueil University Hospital, UMR 1295 INSERM, F-31400 Toulouse, France.

Jean-Michel Lecerf (JM)

Nutrition Department, Institut Pasteur de Lille, CEDEX, F-59019 Lille, France.

Alexa Derksen (A)

Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montréal, QC H3A 0G4, Canada.
Translational Proteomics Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Department of Neurology and Neurosurgery, McGill University, Montréal, QC H3A 0G4, Canada.

Geneviève Bernard (G)

Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montréal, QC H3A 0G4, Canada.
Department of Neurology and Neurosurgery, McGill University, Montréal, QC H3A 0G4, Canada.
Department of Pediatrics, McGill University, Montréal, QC H3A 0G4, Canada.
Department of Human Genetics, McGill University, Montréal, QC H3A 0G4, Canada.
Division of Medical Genetics, Department of Specialized Medicine, McGill University Health Centre, Montréal, QC H4A 3J1, Canada.

Marie-Soleil Gauthier (MS)

Translational Proteomics Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.

Benoit Coulombe (B)

Translational Proteomics Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada.

Dieter Lütjohann (D)

Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, F-53127 Bonn, Germany.

Bertrand Fin (B)

CEA, Centre National de Recherche en Génomique Humaine, Laboratory of Excellence GENMED (Medical Genomics), Paris-Saclay University, F-91057 Evry, France.

Anne Boland (A)

CEA, Centre National de Recherche en Génomique Humaine, Laboratory of Excellence GENMED (Medical Genomics), Paris-Saclay University, F-91057 Evry, France.

Robert Olaso (R)

CEA, Centre National de Recherche en Génomique Humaine, Laboratory of Excellence GENMED (Medical Genomics), Paris-Saclay University, F-91057 Evry, France.

Jean-François Deleuze (JF)

CEA, Centre National de Recherche en Génomique Humaine, Laboratory of Excellence GENMED (Medical Genomics), Paris-Saclay University, F-91057 Evry, France.
Centre d'Etude du Polymorphisme Humain, Fondation Jean Dausset, F-75019 Paris, France.

Jean-Pierre Rabès (JP)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Department of Biochemistry and Molecular Genetics, Ambroise Paré University Hospital (APHP), Université Paris-Saclay, F-92104 Boulogne-Billancourt, France.
UFR (Unite de Formation et de Recherche) Simone Veil-Santé, Versailles-Saint-Quentin-en-Yvelines University, F-78180 Montigny-le-Bretonneux, France.

Catherine Boileau (C)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory for Vascular Translational Science, Paris Cité University, Sorbonne Paris Nord University, F-75013 Paris, France.
Genetic Department, AP-HP, Hôpital Bichat, F-75018 Paris, France.

Marianne Abifadel (M)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory of Biochemistry and Molecular Therapeutics (LBTM), Faculty of Pharmacy, Pôle Technologie-Santé (PTS), Saint-Joseph University, Beirut 1004 2020, Lebanon.

Mathilde Varret (M)

INSERM, Laboratory for Vascular Translational Science (LVTS), F-75018 Paris, France.
Laboratory for Vascular Translational Science, Paris Cité University, Sorbonne Paris Nord University, F-75013 Paris, France.

Classifications MeSH