Blood Pressure Goals in Acute Stroke.
acute stroke
blood pressure
blood pressure goals
guidelines
hypertension
observational studies
randomized controlled trials
Journal
American journal of hypertension
ISSN: 1941-7225
Titre abrégé: Am J Hypertens
Pays: United States
ID NLM: 8803676
Informations de publication
Date de publication:
16 06 2022
16 06 2022
Historique:
received:
12
03
2022
revised:
17
03
2022
accepted:
19
03
2022
pubmed:
25
3
2022
medline:
22
6
2022
entrez:
24
3
2022
Statut:
ppublish
Résumé
Antihypertensive treatment is highly effective in both primary and secondary prevention of stroke. However, current guideline recommendations on the blood pressure goals in acute stroke are clinically empirical and generally conservative. Antihypertensive treatment is only recommended for severe hypertension. Several recent observational studies showed that the relationship between blood pressure and unfavorable clinical outcomes was probably positive in acute hemorrhagic stroke but J- or U-shaped in acute ischemic stroke with undetermined nadir blood pressure. The results of randomized controlled trials are promising for blood pressure management in hemorrhagic stroke but less so in ischemic stroke. A systolic blood pressure goal of 140 mm Hg is probably appropriate for acute hemorrhagic stroke. The blood pressure goal in acute ischemic stroke, however, is uncertain, and probably depends on the time window of treatment and the use of revascularization therapy. Further research is required to investigate the potential benefit of antihypertensive treatment in acute stroke, especially with regard to the possible reduction of blood pressure variability and more intensive blood pressure lowering in the acute and subacute phases of a stroke, respectively.
Identifiants
pubmed: 35323883
pii: 6552292
doi: 10.1093/ajh/hpac039
pmc: PMC9203067
doi:
Substances chimiques
Antihypertensive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
483-499Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd.
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