Seroprevalence of SARS-CoV-2 antibodies among first-trimester pregnant women during the second wave of the pandemic in India.
COVID
SARS-CoV-2
first trimester
pandemic
pregnancy
seroprevalence
wave
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
18
01
2022
accepted:
18
03
2022
pubmed:
25
3
2022
medline:
16
12
2022
entrez:
24
3
2022
Statut:
ppublish
Résumé
Data on the immune response to SARS-CoV-2 during pregnancy are lacking and the potential role and effect of SARS-CoV-2 vaccination in pregnancy is yet to be completely investigated. This is a cross-sectional observational study wherein pregnant women were tested for SARS-CoV-2 immunoglobulin M and immunoglobulin G levels, irrespective of their infective status or presence or symptomatology. Of the 220 pregnant women tested, 160 (72.7%) were SARS-CoV-2 IgG positive, 37 (16.8%) were SARS-CoV-2 IgM positive and 27 (16.9%) were both IgG and IgM positive. The average antibody titer found was 10.49 BAU/ml (±14.0) and 0.6 (±0.55) for anti-SARS-CoV-2 IgG and IgM non neutralizing antibodies respectively. ROC analysis for SARS-CoV-2 IgG positivity showed a cut-off value of 1.19 with a sensitivity of 99.3% (0.99 AUC, 95% CI) and specificity of 98.3% (0.99 AUC, 95% CI), respectively. Similarly, ROC analysis for SARS-CoV-2 IgM positivity showed a cut-off value of 1 with a sensitivity of 97.3% (0.99 AUC, 95% CI) and specificity of 98.9% (0.99 AUC, 95% CI), respectively. First trimester sero-molecular screening suggests a high prevalence of COVID antibodies in the study population of pregnant women in the first trimester, without the patients being symptomatic.
Identifiants
pubmed: 35324007
doi: 10.1002/ijgo.14189
pmc: PMC9087646
doi:
Substances chimiques
COVID-19 Vaccines
0
Antibodies, Viral
0
Immunoglobulin G
0
Immunoglobulin M
0
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-78Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 International Federation of Gynecology and Obstetrics.
Références
Johns Hopkins Coronavirus Resource Center. Jhu.edu. [cited 2021 Oct 11]. Available from: https://coronavirus.jhu.edu/map.html.
Cosma S, Borella F, Carosso A, et al. The “scar” of a pandemic: cumulative incidence of COVID-19 during the first trimester of pregnancy. J Med Virol. 2021;93(1):537-540.
Cosma S, Carosso AR, Cusato J, et al. Coronavirus disease 2019 and first-trimester spontaneous abortion: a case-control study of 225 pregnant patients. Am J Obstet Gynecol. 2021;224(4):391.e1-391.e7.
RCOG Guidelines on coronavirus (COVID) infection in pregnancy. https://www.rcog.org.uk/globalassets/documents/guidelines/2021-08-25-coronavirus-covid-19-infection-in-pregnancy-v14.pdf.
Benedetto C, Carosso A, Corezzi M, Zotti CM. EBCOG EBCOG position statement: vaccination in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2019;240:375-376. doi: 10.1016/j.ejogrb.2019.04.022
Gov.in. [cited 2021 Oct 11]. Available from: https://www.icmr.gov.in/pdf/covid/strategy/New_additional_Advisory_23062020_3
Jiao J. Under the epidemic situation of COVID-19, should special attention to pregnant women be given? J Med Virol. 2020;92(9):1371-1372.
Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395:809-815.
Carosso A, Cosma S, Borella F, et al. Pre-labor anorectal swab for SARS-CoV-2 in COVID-19 patients: is it time to think about it? Eur J Obstet Gynecol Reprod Biol. 2020 Apr 11;249:98-99.
Chen S, Liao E, Cao D, Gao Y, Sun G, Shao Y. Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. J Med Virol. 2020;92(9):1556-1561.
Yan J, Guo J, Fan C, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol. 2020;223(1):111-e1.
Ferrazzi E, Frigerio L, Savasi V, et al. Vaginal delivery in SARS-CoV-2-infected pregnant women in northern Italy: a retrospective analysis. BJOG. 2020;127(9):1116-1121.
Liao J, He X, Gong Q, Yang L, Zhou C, Li J. Analysis of vaginal delivery outcomes among pregnant women in Wuhan, China during the COVID-19 pandemic. Int J Gynaecol Obstet. 2020;150(1):53-57.
Breslin N, Baptiste C, Gyamfi-Bannerman C, et al. COVID-19 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol MFM. 2020;2(2):100118. doi: 10.1016/j.ajogmf.2020.100118
Ali A, Rashid Z, Zhou J, et al. Evaluating antibody response pattern in asymptomatic virus infected pregnant females: human well-being study. J King Saud Univ Sci. 2021;33(1):101255.
Zullo F, Di Mascio D, Saccone G. Coronavirus disease 2019 antibody testing in pregnancy. Am J Obstet Gynecol MFM. 2020;2(3):100142.
Villalaín C, Herraiz I, Luczkowiak J, et al. Seroprevalence analysis of SARS-CoV-2 in pregnant women along the first pandemic outbreak and perinatal outcome. PLoS ONE. 2020;15(11):e0243029. doi: 10.1371/journal.pone.0243029
Baptiste C, Breslin N, Chong A, et al. 919 rates of seroprevalance of COVID-19 among pregnant patients in New York City. Am J Obstet Gynecol. 2021;224(2):S571. doi: 10.1016/j.ajog.2020.12.944