The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABA
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
21
02
2022
received:
22
12
2021
accepted:
23
02
2022
pubmed:
25
3
2022
medline:
11
5
2022
entrez:
24
3
2022
Statut:
ppublish
Résumé
Royal demolition explosive (RDX) can induce seizures in wildlife and humans following release into the environment or after voluntary consumption. During the Vietnam War, RDX intoxication was the most common cause of generalized seizures in US service personnel, and in some sections of the armed forces, eating of RDX has continued as "a dare" to this day. After its mechanism of action was long unknown, RDX was recently shown to be a GABA We used whole-cell patch-clamp to determine the potency of RDX on 10 recombinantly expressed GABA RDX was found to reversibly inhibit the α1β2γ2 GABA Our findings characterize the mechanism of action of RDX at the atomistic level and suggest that RDX-induced seizures should be susceptible to treatment with GABA
Identifiants
pubmed: 35324073
doi: 10.1002/acn3.51536
pmc: PMC9082378
doi:
Substances chimiques
Plastics
0
Receptors, GABA-A
0
Triazines
0
gamma-Aminobutyric Acid
56-12-2
cyclonite
W91SSV5831
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
600-609Subventions
Organisme : NINDS NIH HHS
ID : R21 NS110647
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM099608
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS079202
Pays : United States
Informations de copyright
© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
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