Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products.
allogeneic cell therapy
cell aggregate
computational fluid dynamics
differentiation
expansion
homogeneous hydrodynamic environment
human embryonic stem cell
induced pluripotent stem cell
medium exchange
oxygenation
scalable manufacturing
scale up
shear stress
single-use bioreactor
turbulent energy dissipation rate
vertical-wheel
Journal
Bioengineering (Basel, Switzerland)
ISSN: 2306-5354
Titre abrégé: Bioengineering (Basel)
Pays: Switzerland
ID NLM: 101676056
Informations de publication
Date de publication:
25 Feb 2022
25 Feb 2022
Historique:
received:
04
01
2022
revised:
10
02
2022
accepted:
14
02
2022
entrez:
24
3
2022
pubmed:
25
3
2022
medline:
25
3
2022
Statut:
epublish
Résumé
Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of patients globally. However, there are various challenges related to manufacturing PSCs in single-use bioreactors, particularly at larger volumetric scales. This manuscript addresses these challenges and presents potential solutions to alleviate the anticipated bottlenecks for commercial-scale manufacturing of high-quality therapeutic cells derived from PSCs.
Identifiants
pubmed: 35324781
pii: bioengineering9030092
doi: 10.3390/bioengineering9030092
pmc: PMC8945133
pii:
doi:
Types de publication
Journal Article
Langues
eng
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