Oral health status after hematopoietic stem cell transplantations: Outcomes from an adult Italian population.
hematopoietic stem cell transplantation
hyposalivation
oral graft-versus-host disease
oral health
oral status
Journal
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
ISSN: 1754-4505
Titre abrégé: Spec Care Dentist
Pays: United States
ID NLM: 8103755
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
revised:
02
03
2022
received:
05
01
2022
accepted:
04
03
2022
pubmed:
25
3
2022
medline:
11
11
2022
entrez:
24
3
2022
Statut:
ppublish
Résumé
To describe oral cavity changes in patients who underwent a hematopoietic stem cell transplantation (HSCT). A group of 32 patients was studied after a mean period of 48.8 months (±11.22) from HSCT; oral, dental, and periodontal status were collected and compared with those of healthy matched controls. Unstimulated whole salivary flow (UWS) and salivary pH were also measured. A validated questionnaire (EORTC QLQH&N-35) was used for reported quality of life. Fifty-nine percent of patients were affected by chronic graft-versus-host disease (cGVHD). Dental health and periodontal status were statistically worse than in controls (P = .003 and P = .008, respectively). Regarding the HSCT group, UWS was statistically lower, and EORTC QLQH&N-35 significantly higher than those reported in controls (P = .000 for both). There was no statistical correlation between hypo-salivation and conditioning, presence of cGVHD, type of medication used before and after transplantation, and time of follow-up. A reduction in salivary pH has been noted only for patients with erosive oral lesions. The oral cavity of HSCT patients appeared to undergo substantial modifications and the quality of life was deeply compromised.
Types de publication
Journal Article
Langues
eng
Pagination
585-591Informations de copyright
© 2022 Special Care Dentistry Association and Wiley Periodicals LLC.
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