A Dynamic Model for Estimating the Interaction of ROS-PUFA-Antioxidants in Rabbit.
antioxidants
dynamic model
metabolism
oxidation
polyunsaturated fatty acids
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
10 Mar 2022
10 Mar 2022
Historique:
received:
01
02
2022
revised:
07
03
2022
accepted:
09
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Defining optimal nutrition in animals and humans remains a main scientific challenge. The objective of the work was to develop a dynamic model of reactive oxygen species (ROS)-polyunsaturated fatty acid (PUFA)-antioxidant homeostasis using the rabbit as a model. The problem entity was to evaluate the main metabolites generated from interactions between traits included in the conceptual model and identified by three main sub-models: (i) ROS generation, (ii) PUFA oxidation and (iii) antioxidant defence. A mathematical model (VENSIM software) that consisted of molecular stocks (INPUTs, OUTPUTs), exchange flows (intermediate OUTPUTs) and process rates was developed. The calibration was performed by using standard experimental data (Experiment 1), whereas the validation was carried out in Experiments 2 and 3 by using supra-nutritional dietary inputs (VIT E+ and PUFA+). The accuracy of the models was measured using 95% confidence intervals. Analytical OUTPUTs (ROS, PUFA, Vit E, Ascorbic acid, Iso-/NeuroProstanes, Aldehydes) were well described by the standard model. There was also good accuracy for the VIT E+ scenario, whereas some compensatory rates (K
Identifiants
pubmed: 35326181
pii: antiox11030531
doi: 10.3390/antiox11030531
pmc: PMC8944554
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Nature. 2009 Jun 18;459(7249):996-9
pubmed: 19494811
IUBMB Life. 2022 Jan;74(1):24-28
pubmed: 34227739
Free Radic Biol Med. 1999 Nov;27(9-10):916-21
pubmed: 10569624
Reprod Domest Anim. 2007 Jun;42(3):248-56
pubmed: 17506802
J Food Biochem. 2020 Mar;44(3):e13145
pubmed: 31960481
Redox Biol. 2015;4:193-9
pubmed: 25598486
Life (Basel). 2021 Jul 05;11(7):
pubmed: 34357027
Acc Chem Res. 2010 Feb 16;43(2):280-7
pubmed: 19938827
Chem Rev. 2004 Sep;104(9):3947-80
pubmed: 15352783
Chem Biol Interact. 2019 Nov 1;313:108821
pubmed: 31525342
Nutrients. 2015 Mar 31;7(4):2209-36
pubmed: 25835046
Stud Health Technol Inform. 2014;203:185-92
pubmed: 26630524
Essays Biochem. 2020 Sep 23;64(3):463-484
pubmed: 32602531
Int J Androl. 1997 Apr;20(2):61-9
pubmed: 9292315
Antioxidants (Basel). 2021 Apr 27;10(5):
pubmed: 33925444
Chem Soc Rev. 2010 Nov;39(11):4067-79
pubmed: 20617249
Swiss Med Wkly. 2012 Aug 17;142:w13659
pubmed: 22903797
Free Radic Biol Med. 2019 Feb 1;131:115-125
pubmed: 30508576
FEBS Lett. 2000 Jul 7;476(3):218-23
pubmed: 10913617
Nature. 2011 Mar 31;471(7340):661-5
pubmed: 21455183
Poult Sci. 2000 Jul;79(7):961-70
pubmed: 10901194
Free Radic Biol Med. 2019 Aug 1;139:46-54
pubmed: 31100476
Free Radic Biol Med. 2021 Nov 20;176:142-148
pubmed: 34562608
Food Biosci. 2013 Dec 1;4:1-12
pubmed: 24511462
Nature. 2000 Nov 9;408(6809):239-47
pubmed: 11089981
Proc Natl Acad Sci U S A. 2022 Jan 11;119(2):
pubmed: 34996868
Animal. 2019 Sep;13(9):1934-1942
pubmed: 30774049
Physiol Rev. 1979 Jul;59(3):527-605
pubmed: 37532
J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):197-200
pubmed: 7952068
J Nutr Biochem. 2017 Sep;47:120-131
pubmed: 28628909
J Biol Chem. 1957 May;226(1):497-509
pubmed: 13428781
J Chromatogr. 1992 May 8;576(2):221-33
pubmed: 1400710
World J Mens Health. 2014 Apr;32(1):1-17
pubmed: 24872947
Antioxidants (Basel). 2021 Jan 25;10(2):
pubmed: 33503988
Oxid Med Cell Longev. 2019 Dec 16;2019:3279670
pubmed: 32082475
Cell Metab. 2011 Apr 6;13(4):361-366
pubmed: 21459321
Lipids. 2007 Nov;42(11):1065-71
pubmed: 17701238
J Biol Chem. 1994 Apr 1;269(13):9397-400
pubmed: 8144521
Free Radic Biol Med. 2017 Jan;102:16-36
pubmed: 27816611
Prostaglandins Other Lipid Mediat. 2020 Aug;149:106448
pubmed: 32272165
J Lipid Res. 1982 Sep;23(7):1072-5
pubmed: 6897259
Free Radic Res. 1999 Oct;31(4):261-72
pubmed: 10517532
Animals (Basel). 2019 Oct 15;9(10):
pubmed: 31618904
J Trace Elem Med Biol. 2019 Jan;51:98-105
pubmed: 30466946
Trends Biochem Sci. 2018 Nov;43(11):854-857
pubmed: 29735398
Meat Sci. 2018 Sep;143:230-236
pubmed: 29803133
Plant Cell. 2005 Jul;17(7):1866-75
pubmed: 15987996
Antioxid Redox Signal. 2015 Jul 20;23(3):239-55
pubmed: 25178482
Vitam Horm. 2007;76:263-80
pubmed: 17628177
Theriogenology. 2002 Dec;58(9):1723-32
pubmed: 12472142
Cell Rep. 2020 Nov 10;33(6):108368
pubmed: 33176146
Free Radic Biol Med. 2007 Jul 1;43(1):4-15
pubmed: 17561088
Poult Sci. 2019 Oct 1;98(10):4240-4246
pubmed: 30371893
Nature. 2003 Mar 27;422(6930):442-6
pubmed: 12660786
Lipids. 2014 May;49(5):431-44
pubmed: 24627299
Biochim Biophys Acta. 2015 Apr;1851(4):433-45
pubmed: 25449649
Redox Biol. 2015;4:180-3
pubmed: 25588755