Synapsin II Directly Suppresses Epileptic Seizures In Vivo.
4-AP
AAV
EPSC
PKA
epileptiform
synapse
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
28 Feb 2022
28 Feb 2022
Historique:
received:
30
01
2022
revised:
22
02
2022
accepted:
24
02
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
The synapsin family offers a strong linkage between synaptic mechanisms and the epileptic phenotype. Synapsins are phosphoproteins reversibly associated with synaptic vesicles. Synapsin deficiency can cause epilepsy in humans, and synapsin II (SynII) in knockout (KO) mice causes generalized epileptic seizures. To differentiate between the direct effect of SynII versus its secondary adaptations, we used neonatal intracerebroventricular injections of the adeno-associated virus (AAV) expressing SynII. We found that SynII reintroduction diminished the enhanced synaptic activity in
Identifiants
pubmed: 35326282
pii: brainsci12030325
doi: 10.3390/brainsci12030325
pmc: PMC8946686
pii:
doi:
Types de publication
Journal Article
Langues
eng
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