Current Methods to Unravel the Functional Properties of Lysosomal Ion Channels and Transporters.
ion channels
lysosomes
patch-clamp
plant vacuole
transporters
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
08 03 2022
08 03 2022
Historique:
received:
10
02
2022
revised:
04
03
2022
accepted:
05
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
14
4
2022
Statut:
epublish
Résumé
A distinct set of channels and transporters regulates the ion fluxes across the lysosomal membrane. Malfunctioning of these transport proteins and the resulting ionic imbalance is involved in various human diseases, such as lysosomal storage disorders, cancer, as well as metabolic and neurodegenerative diseases. As a consequence, these proteins have stimulated strong interest for their suitability as possible drug targets. A detailed functional characterization of many lysosomal channels and transporters is lacking, mainly due to technical difficulties in applying the standard patch-clamp technique to these small intracellular compartments. In this review, we focus on current methods used to unravel the functional properties of lysosomal ion channels and transporters, stressing their advantages and disadvantages and evaluating their fields of applicability.
Identifiants
pubmed: 35326372
pii: cells11060921
doi: 10.3390/cells11060921
pmc: PMC8946281
pii:
doi:
Substances chimiques
Ion Channels
0
Ions
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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