Protective Effect of Human-Neural-Crest-Derived Nasal Turbinate Stem Cells against Amyloid-β Neurotoxicity through Inhibition of Osteopontin in a Human Cerebral Organoid Model of Alzheimer's Disease.
Alzheimer’s disease
amyloid-β peptide
hNTSCs
human brain organoid
osteopontin
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
18 03 2022
18 03 2022
Historique:
received:
23
02
2022
revised:
14
03
2022
accepted:
16
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
13
4
2022
Statut:
epublish
Résumé
The aim of this study was to validate the use of human brain organoids (hBOs) to investigate the therapeutic potential and mechanism of human-neural-crest-derived nasal turbinate stem cells (hNTSCs) in models of Alzheimer's disease (AD). We generated hBOs from human induced pluripotent stem cells, investigated their characteristics according to neuronal markers and electrophysiological features, and then evaluated the protective effect of hNTSCs against amyloid-β peptide (Aβ
Identifiants
pubmed: 35326480
pii: cells11061029
doi: 10.3390/cells11061029
pmc: PMC8947560
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Osteopontin
106441-73-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Basic Science Research Program and the Bio & Medical Technology Development Program through a National Research Foundation of Korea (NRF) grant funded by the Ministry of Education
ID : 2019R1F1A104119713, 2020R1I1A1A01070352, 2021R1C1C201046911, 2021M3F7A1083232
Organisme : the Korean government (MSIT)
ID : 2019M3E5D506411
Organisme : the Ministry of Science & ICT
ID : 2019M3A9H2032424
Organisme : the Catholic Medical Center Research Foundation made in the program year of 2019, by Research Fund of Seoul St.Mary's Hospital, The Catholic University of Korea
ID : ZC21CESI0573
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