Celastrol and Resveratrol Modulate
cancer stem cells
celastrol
colon cancer
resveratrol
sirtuins
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Mar 2022
08 Mar 2022
Historique:
received:
24
01
2022
revised:
24
02
2022
accepted:
06
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Metastatic colorectal cancer (CRC) remains a hard-to-cure neoplasm worldwide. Its curability declines with successive lines of treatment due to the development of various cancer resistance mechanisms and the presence of colorectal cancer stem cells (CSCs). Celastrol and resveratrol are very promising phytochemicals for colon cancer therapy, owing to their pleiotropic activity that enables them to interact with various biological targets. In the present study, the anticancer activities of both compounds were investigated in metastatic colon cancer cells (LoVo cells) and cancer stem-like cells (LoVo/DX). We showed that celastrol is a very potent anti-tumor compound against metastatic colon cancer, capable of attenuating CSC-like cells at the molecular and cellular levels. In contrast, resveratrol has a much greater effect on colon cancer cells that are expressing standard sensitivity to anticancer drugs, than on CSC-like cells. In addition, both polyphenols have different influences on the expression of
Identifiants
pubmed: 35326523
pii: cancers14061372
doi: 10.3390/cancers14061372
pmc: PMC8945991
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Wroclaw Medical University Grant
ID : SUB.D.130.19.040
Organisme : Wroclaw Medical University Grant
ID : ST.D130.16.009
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