The Fra-1/AP-1 Oncoprotein: From the "Undruggable" Transcription Factor to Therapeutic Targeting.
AP-1 complex
FOSL1
Fos-Related-Antigen-1
therapeutic targeting
transcription factor
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
14 Mar 2022
14 Mar 2022
Historique:
received:
04
02
2022
revised:
04
03
2022
accepted:
10
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
The genetic and epigenetic changes affecting transcription factors, coactivators, and chromatin modifiers are key determinants of the hallmarks of cancer. The acquired dependence on oncogenic transcriptional regulators, representing a major determinant of cancer cell vulnerability, points to transcription factors as ideal therapeutic targets. However, given the unavailability of catalytic activities or binding pockets for small-molecule inhibitors, transcription factors are generally regarded as undruggable proteins. Among components of the AP-1 complex, the FOS-family transcription factor Fra-1, encoded by
Identifiants
pubmed: 35326630
pii: cancers14061480
doi: 10.3390/cancers14061480
pmc: PMC8946526
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19408-13
pubmed: 23129625
Theranostics. 2020 Feb 19;10(8):3708-3721
pubmed: 32206117
Cancer Lett. 2021 May 28;506:23-34
pubmed: 33652085
Br J Cancer. 2020 May;122(11):1630-1637
pubmed: 32238921
Mol Ther. 2021 Feb 3;29(2):431-432
pubmed: 33472033
Crit Rev Food Sci Nutr. 2009 Oct;49(9):782-99
pubmed: 20443159
Cancer Cell. 2013 Oct 14;24(4):466-80
pubmed: 24075834
Breast Cancer Res. 2018 Jan 30;20(1):9
pubmed: 29382358
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5826-30
pubmed: 9159159
Elife. 2016 Jul 19;5:
pubmed: 27434673
Oncogene. 2010 Aug 19;29(33):4732-40
pubmed: 20543861
Mol Ther. 2021 Aug 4;29(8):2583-2600
pubmed: 33794365
Nat Cell Biol. 2015 Sep;17(9):1218-27
pubmed: 26258633
Sci Signal. 2016 Oct 04;9(448):ra97
pubmed: 27703030
Nature. 2010 Dec 16;468(7326):927-32
pubmed: 21164480
J Exp Med. 2017 Jun 5;214(6):1753-1767
pubmed: 28465464
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20723-8
pubmed: 24297898
Nature. 2021 Aug;596(7873):590-596
pubmed: 34293799
J Med Chem. 2004 Aug 12;47(17):4239-46
pubmed: 15293995
Onco Targets Ther. 2016 Oct 25;9:6597-6604
pubmed: 27822064
Cell Death Differ. 2015 Feb;22(2):336-50
pubmed: 25301070
Mol Cell Biol. 2003 Jun;23(12):4401-15
pubmed: 12773579
ACS Chem Biol. 2017 Aug 18;12(8):2051-2061
pubmed: 28636317
Biochimie. 2008 Feb;90(2):296-305
pubmed: 17825471
Mol Cell. 2010 Apr 9;38(1):114-27
pubmed: 20385094
Mol Cell. 2020 Jun 18;78(6):1096-1113.e8
pubmed: 32416067
Mol Cancer Ther. 2016 May;15(5):1018-28
pubmed: 26908627
Oncogene. 2013 Sep 5;32(36):4294-303
pubmed: 23001043
Oncogene. 2020 Jun;39(23):4491-4506
pubmed: 32385348
Cancer Cell. 2010 Sep 14;18(3):282-93
pubmed: 20832755
Cell Rep. 2016 Feb 9;14(5):1169-1180
pubmed: 26832411
Cancer Discov. 2018 Jan;8(1):24-36
pubmed: 29263030
Cancer Cell. 2019 Nov 11;36(5):498-511.e17
pubmed: 31715132
Oncogene. 2015 Aug 20;34(34):4421-8
pubmed: 25381818
Nat Rev Clin Oncol. 2017 Oct;14(10):611-629
pubmed: 28397828
Cell Death Dis. 2016 May 05;7:e2211
pubmed: 27148684
J Med Chem. 2014 Aug 28;57(16):6930-48
pubmed: 24831826
Crit Rev Oncog. 2013;18(1-2):115-33
pubmed: 23237555
Am J Transl Res. 2020 Feb 15;12(2):409-427
pubmed: 32194893
Cancer Discov. 2018 Jan;8(1):74-93
pubmed: 28923912
PLoS One. 2012;7(7):e41611
pubmed: 22911824
Theranostics. 2020 Aug 8;10(22):10141-10153
pubmed: 32929339
Mol Cancer Ther. 2015 Oct;14(10):2279-91
pubmed: 26264278
RSC Chem Biol. 2021 Jan 29;2(2):656-668
pubmed: 34458807
PLoS Genet. 2013;9(9):e1003777
pubmed: 24039610
Cell Rep. 2021 Jul 27;36(4):109443
pubmed: 34320363
Front Oncol. 2021 Apr 16;11:656628
pubmed: 33937067
Nucleic Acids Res. 2018 Jan 25;46(2):546-557
pubmed: 29237043
Nat Commun. 2017 Feb 21;8:14294
pubmed: 28220783
Anticancer Drugs. 2020 Nov;31(10):1026-1037
pubmed: 32868647
Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18295-18303
pubmed: 31451668
Biochim Biophys Acta Rev Cancer. 2019 Aug;1872(1):11-23
pubmed: 31034924
Genome Res. 2018 Jan 11;:
pubmed: 29326299
Nature. 2019 Apr;568(7753):511-516
pubmed: 30971826
Cell. 2013 Nov 7;155(4):934-47
pubmed: 24119843
Trends Cancer. 2020 Sep;6(9):775-780
pubmed: 32312682
Oncogene. 2017 Sep 7;36(36):5110-5121
pubmed: 28481878
Nat Rev Cancer. 2002 Oct;2(10):740-9
pubmed: 12360277
Sci Rep. 2017 Dec 5;7(1):16983
pubmed: 29208967
Cancer Res. 2014 Jul 15;74(14):3983-94
pubmed: 24830720
EMBO J. 2007 Apr 4;26(7):1878-90
pubmed: 17347653
J Cell Sci. 2004 Dec 1;117(Pt 25):5965-73
pubmed: 15564374
Oncogene. 2009 Jan 8;28(1):73-84
pubmed: 18850008
Cancer Res. 2017 Aug 1;77(15):3982-3989
pubmed: 28428275
Cancer Res. 2006 Aug 1;66(15):7578-88
pubmed: 16885357
Nat Biotechnol. 2008 Jul;26(7):817-23
pubmed: 18587386
J Cell Physiol. 2008 Aug;216(2):405-12
pubmed: 18288638
Am J Respir Cell Mol Biol. 2018 May;58(5):625-635
pubmed: 29112457
Oncogene. 2022 Feb;41(6):907-919
pubmed: 34992218
Sci Signal. 2011 Jun 14;4(177):ra41
pubmed: 21673316
J Biol Chem. 2005 Mar 11;280(10):9706-18
pubmed: 15615716
Cell. 2013 Apr 11;153(2):320-34
pubmed: 23582323
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Carcinogenesis. 2020 Jul 10;41(6):723-733
pubmed: 31665243
Mol Cell. 2013 Jan 24;49(2):249-61
pubmed: 23219535
Mol Ther. 2021 Apr 7;29(4):1585-1601
pubmed: 33333291
Elife. 2021 Aug 17;10:
pubmed: 34399888
Carcinogenesis. 2015 Apr;36(4):459-68
pubmed: 25750173
Oncogene. 2018 Nov;37(48):6195-6211
pubmed: 30002444
Transl Oncol. 2021 Aug;14(8):101100
pubmed: 33993098
Cell. 2010 Mar 5;140(5):744-52
pubmed: 20211142
Oncogene. 1993 Apr;8(4):877-86
pubmed: 8455942
Genome Res. 2018 Feb;28(2):159-170
pubmed: 29273624
Oncogene. 2019 Jul;38(28):5725-5738
pubmed: 31015574
Nat Chem Biol. 2018 Apr;14(4):405-412
pubmed: 29507391
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5139-44
pubmed: 23483055
Biomedicines. 2017 Aug 09;5(3):
pubmed: 28792479
Nature. 2017 Oct 12;550(7675):270-274
pubmed: 28976960
Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9827-32
pubmed: 10449779
Carcinogenesis. 2012 Mar;33(3):519-28
pubmed: 22198213
Oncogene. 2012 Mar 22;31(12):1493-503
pubmed: 21822309
Sci Rep. 2017 Aug 8;7(1):7522
pubmed: 28790303
Ann Surg Oncol. 2017 Oct;24(11):3446-3455
pubmed: 27882471
Oncotarget. 2015 Dec 22;6(41):43146-61
pubmed: 26646695
Oncogene. 2010 Feb 4;29(5):662-73
pubmed: 19966854
Nature. 2010 Dec 23;468(7327):1067-73
pubmed: 20871596
Nat Rev Cancer. 2003 Nov;3(11):859-68
pubmed: 14668816
Melanoma Res. 2015 Dec;25(6):559-63
pubmed: 26397052
Nat Rev Cancer. 2019 Nov;19(11):611-624
pubmed: 31511663
Oncogene. 2012 Apr 5;31(14):1817-24
pubmed: 21874050
Oncol Rep. 2020 Oct;44(4):1365-1374
pubmed: 32945473
Mol Cell. 2020 Jul 2;79(1):155-166.e9
pubmed: 32454028
J Clin Invest. 2019 May 28;129(8):3293-3309
pubmed: 31135379
Cancer Cell. 2013 Sep 9;24(3):347-64
pubmed: 24029232
Mol Ther. 2019 Aug 7;27(8):1350-1363
pubmed: 31324392
Cancer. 2012 Jul 1;118(13):3387-96
pubmed: 22028113
Oncogene. 2014 Jun 5;33(23):3014-23
pubmed: 23831570
Oncogene. 2019 Jun;38(25):4932-4947
pubmed: 30804456
Cancer Sci. 2016 May;107(5):666-73
pubmed: 26918517
J Hepatol. 2021 Aug;75(2):363-376
pubmed: 33887357
Oncotarget. 2017 Mar 15;8(13):20572-20587
pubmed: 28411283
Mol Biol Rep. 2020 Jan;47(1):737-752
pubmed: 31612408
J Am Chem Soc. 2021 Jun 16;143(23):8902-8910
pubmed: 34100597
Cell Death Dis. 2016 Sep 29;7(9):e2384
pubmed: 27685628
Lung Cancer. 2012 Jun;76(3):292-9
pubmed: 22133747
Biosci Rep. 2017 Mar 27;37(2):
pubmed: 28232512
EMBO Mol Med. 2016 Oct 4;8(10):1143-1161
pubmed: 27596438
Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):
pubmed: 33627408
Trends Pharmacol Sci. 2019 Jun;40(6):388-402
pubmed: 31078321
J Med Chem. 2016 Feb 25;59(4):1642-7
pubmed: 25974391
Nature. 2013 Feb 14;494(7436):251-5
pubmed: 23302800
Cancer Cell. 2016 Jun 13;29(6):846-858
pubmed: 27238081
Oncogene. 2012 Nov 22;31(47):4889-97
pubmed: 22286759
Cancer Cell. 2018 Nov 12;34(5):807-822.e7
pubmed: 30423298
Mol Cancer Res. 2019 Oct;17(10):1999-2014
pubmed: 31300541
Mol Cell Biol. 2007 Jun;27(11):3936-50
pubmed: 17371847
Cancers (Basel). 2020 Jan 14;12(1):
pubmed: 31947604
Cell. 2009 Sep 18;138(6):1122-36
pubmed: 19766566
Cancer Gene Ther. 2002 Jan;9(1):62-70
pubmed: 11916245
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
J Biol Chem. 1997 Jul 25;272(30):18586-94
pubmed: 9228025
Sci Rep. 2015 May 06;5:10120
pubmed: 25944566
Nucleic Acids Res. 2021 Mar 18;49(5):2488-2508
pubmed: 33533919
Nat Biotechnol. 2015 Jun;33(6):661-7
pubmed: 25961408
Cell Res. 2010 Jun;20(6):701-12
pubmed: 20386569
EMBO J. 2020 Sep 1;39(17):e103209
pubmed: 32692442
Nat Commun. 2017 Nov 13;8(1):1454
pubmed: 29129908
Cancer Res. 2019 Feb 1;79(3):625-638
pubmed: 30563891
Mol Ther Nucleic Acids. 2020 Jun 5;20:409-420
pubmed: 32244168
PLoS One. 2014 Mar 21;9(3):e88950
pubmed: 24658684
Science. 2015 Jun 19;348(6241):1376-81
pubmed: 25999370
Cancer Res. 2007 Jul 1;67(13):6204-11
pubmed: 17616677
Int J Mol Sci. 2021 Mar 24;22(7):
pubmed: 33804856
Nat Rev Drug Discov. 2017 Mar;16(3):181-202
pubmed: 27807347
Mol Cancer Res. 2007 May;5(5):485-96
pubmed: 17510314