Development of Low-Grade Serous Ovarian Carcinoma from Benign Ovarian Serous Cystadenoma Cells.

KRAS PIK3CA carcinogenesis low-grade serous ovarian carcinoma ovarian cancer ovarian serous cystadenoma

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
15 Mar 2022
Historique:
received: 01 02 2022
revised: 09 03 2022
accepted: 12 03 2022
entrez: 25 3 2022
pubmed: 26 3 2022
medline: 26 3 2022
Statut: epublish

Résumé

Despite the knowledge about numerous genetic mutations essential for the progression of low-grade serous ovarian carcinoma (LGSOC), the specific combination of mutations required remains unclear. Here, we aimed to recognize the oncogenic mutations responsible for the stepwise development of LGSOC using immortalized HOVs-cyst-1 cells, developed from ovarian serous cystadenoma cells, and immortalized via

Identifiants

pubmed: 35326657
pii: cancers14061506
doi: 10.3390/cancers14061506
pmc: PMC8946187
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Puja Dey (P)

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Kentaro Nakayama (K)

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Sultana Razia (S)

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Masako Ishikawa (M)

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Tomoka Ishibashi (T)

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Hitomi Yamashita (H)

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Kosuke Kanno (K)

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Seiya Sato (S)

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Tohru Kiyono (T)

Project for Prevention of HPV-Related Cancer, National Cancer Center, Exploratory Oncology Research and Clinical Trial Center (EPOC), Kashiwa 277-8577, Japan.

Satoru Kyo (S)

Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Classifications MeSH